Decaprenylphosphoryl-beta-D-ribose oxidase · SINGLE PROTEIN · Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
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As of 2026-09-15Decaprenylphosphoryl-beta-D-ribose oxidase shows clinical signal disease relevance led by tuberculosis. 1 more disease program remain visible in the same review block. 2 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P9WJF1. Start with tuberculosis, then reuse UniProt P9WJF1 as the stable protein anchor across project notes and exports.
Start with tuberculosis, then reuse UniProt P9WJF1 as the stable protein anchor across project notes and exports.
Decaprenylphosphoryl-beta-D-ribose oxidase shows clinical signal disease relevance led by tuberculosis. 1 more disease program remain visible in the same review block. 2 linked drugs remain visible in the same block.
Start review with tuberculosis because it currently carries clinical signal support. Linked drugs include MACOZINONE, TBA-7371. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyDecaprenylphosphoryl-beta-D-ribose oxidase
Review this target as Decaprenylphosphoryl-beta-D-ribose oxidase, mapped to UniProt P9WJF1. Sequence length is 461 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Decaprenylphosphoryl-beta-D-ribose oxidase as ChEMBL target CHEMBL3804751, mapped to UniProt P9WJF1. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Decaprenylphosphoryl-beta-D-ribose oxidase is the right protein anchor across sources, using UniProt P9WJF1 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why tuberculosis is currently framed as clinical signal support. It currently carries 2 linked drugs in the same disease frame.
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| Preferred Name | Decaprenylphosphoryl-beta-D-ribose oxidase |
| Target Type | SINGLE PROTEIN |
| Organism | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
| UniProt | P9WJF1 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Decaprenylphosphoryl-beta-D-ribose oxidase |
| UniProt Accession | P9WJF1 |
| Component Type | Protein |
| Sequence Length | 461 aa |
Decaprenylphosphoryl-beta-D-ribose oxidase
Review this target as Decaprenylphosphoryl-beta-D-ribose oxidase, mapped to UniProt P9WJF1. Sequence length is 461 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Decaprenylphosphoryl-beta-D-ribose oxidase shows clinical signal disease relevance led by tuberculosis. 1 more disease program remain visible in the same review block.
Start review with tuberculosis because it currently carries clinical signal support. Linked drugs include MACOZINONE, TBA-7371. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3330226 | 8.0 | IC50 | 10.0 | Clinical |
| CHEMBL5180878 | 8.0 | IC50 | 10.0 | Preclinical |
| CHEMBL5564800 | 7.75 | IC50 | 18.0 | Preclinical |
| CHEMBL5566657 | 7.64 | IC50 | 23.0 | Preclinical |
| CHEMBL4453252 | 7.52 | IC50 | 30.0 | Preclinical |
| CHEMBL4439876 | 7.5 | IC50 | 31.62 | Preclinical |
| CHEMBL1976041 | 7.39 | IC50 | 41.0 | Preclinical |
| CHEMBL4591732 | 7.3 | IC50 | 50.0 | Preclinical |
| CHEMBL4868912 | 7.3 | IC50 | 50.0 | Preclinical |
| CHEMBL3262462 | 7.28 | IC50 | 53.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 47 | 12 | 6.5 |
| assay format | 7 | 31 | 6.1 |
| cell-based format | 3 | 85 | 6.1 |