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Target Snapshot

CHEMBL3807 Target Snapshot

Tyrosine-protein phosphatase non-receptor type 2 · SINGLE PROTEIN · Homo sapiens

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1,245Compounds
213Assays
0Approved Drugs
1,248.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P17706. Use UniProt P17706 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P17706 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Tyrosine-protein phosphatase non-receptor type 2 as ChEMBL target CHEMBL3807, mapped to UniProt P17706. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Tyrosine-protein phosphatase non-receptor type 2
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL3807
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P17706
Tyrosine-protein phosphatase non-receptor type 2
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Tyrosine-protein phosphatase non-receptor type 2 is the right protein anchor across sources, using UniProt P17706 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NameTyrosine-protein phosphatase non-receptor type 2
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtP17706
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelTyrosine-protein phosphatase non-receptor type 2
UniProt AccessionP17706
Component TypeProtein
Sequence Length415 aa

Tyrosine-protein phosphatase non-receptor type 2

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Tyrosine-protein phosphatase non-receptor type 2, mapped to UniProt P17706. Sequence length is 415 aa.

Mapped IDP17706
Review nameTyrosine-protein phosphatase non-receptor type 2
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

3
Phase II
Assay Mix

Activity Type Distribution

IC501,093.0
KI154.0
KD1.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5619806 9.24 IC50 0.58 Preclinical
CHEMBL5076419 9.0 IC50 1.0 Preclinical
CHEMBL5084112 9.0 IC50 1.0 Preclinical
CHEMBL5095164 8.74 IC50 1.8 Clinical
CHEMBL230751 8.7 Ki 2.0 Preclinical
CHEMBL230860 8.7 Ki 2.0 Preclinical
CHEMBL230862 8.7 Ki 2.0 Preclinical
CHEMBL395722 8.7 Ki 2.0 Preclinical
CHEMBL5618445 8.7 IC50 2.0 Preclinical
CHEMBL269166 8.52 IC50 3.0 Preclinical
Distribution

pChEMBL Value Distribution

212
5.0
94
5.5
94
6.0
36
6.5
37
7.0
28
7.5
34
8.0
11
8.5
3
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

213
Total Assays
852
Tested Compounds
2
Assay Types
Binding — 209 assays, 852 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 150 583 5.7
assay format 41 219 4.8
cell-based format 18 50 6.2
ADME — 4 assays, 10 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 2 0 —
single protein format 2 10 5.6

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine