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Target Snapshot

CHEMBL3813 Target Snapshot

Dipeptidyl peptidase 4 · SINGLE PROTEIN · Sus scrofa

140Compounds
20Assays
0Approved Drugs
119.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P22411. Use UniProt P22411 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P22411 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Dipeptidyl peptidase 4 as ChEMBL target CHEMBL3813, mapped to UniProt P22411. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Dipeptidyl peptidase 4
SINGLE PROTEIN · Sus scrofa
As of 2026-09-14
ChEMBL target ID
CHEMBL3813
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P22411
Dipeptidyl peptidase 4
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Dipeptidyl peptidase 4 is the right protein anchor across sources, using UniProt P22411 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelDipeptidyl peptidase 4
UniProt AccessionP22411
Component TypeProtein
Sequence Length766 aa

Dipeptidyl peptidase 4

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Dipeptidyl peptidase 4, mapped to UniProt P22411. Sequence length is 766 aa.

Mapped IDP22411
Review nameDipeptidyl peptidase 4
OrganismSus scrofa
Assay Mix

Activity Type Distribution

IC5095.0
KI24.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL2408771 10.32 IC50 0.048 Preclinical
CHEMBL237488 9.14 IC50 0.73 Preclinical
CHEMBL2408655 9.0 IC50 1.0 Preclinical
CHEMBL1627326 8.7 Ki 2.0 Preclinical
CHEMBL86677 8.4 Ki 4.0 Preclinical
CHEMBL2408638 8.19 IC50 6.5 Preclinical
CHEMBL86800 8.15 Ki 7.0 Preclinical
CHEMBL88949 8.15 Ki 7.0 Preclinical
CHEMBL1627303 8.1 Ki 8.0 Preclinical
CHEMBL89666 8.1 Ki 8.0 Preclinical
Distribution

pChEMBL Value Distribution

9
5.0
16
5.5
25
6.0
25
6.5
8
7.0
11
7.5
7
8.0
2
8.5
2
9.0
1
9.5
pChEMBL
Assay Landscape

Assay Landscape

20
Total Assays
101
Tested Compounds
3
Assay Types
Binding — 15 assays, 101 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 15 101 6.6
ADME — 4 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 4 0
Functional — 1 assays, 4 compounds
BAO Format Assays Compounds Avg pChEMBL
tissue-based format 1 4 6.1

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine