Use UniProt Q92947 as the stable identity anchor, then attach disease evidence before program review.
CHEMBL3817721 Target Snapshot
Glutaryl-CoA dehydrogenase, mitochondrial · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q92947. Use UniProt Q92947 as the stable identity anchor, then attach disease evidence before program review.
Glutaryl-CoA dehydrogenase, mitochondrial
Review this target as Glutaryl-CoA dehydrogenase, mitochondrial, mapped to UniProt Q92947. Sequence length is 438 aa.
Protein source · UniProt accession via ChEMBL component mappingCross-source identity
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This review treats Glutaryl-CoA dehydrogenase, mitochondrial as ChEMBL target CHEMBL3817721, mapped to UniProt Q92947. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Glutaryl-CoA dehydrogenase, mitochondrial |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q92947 |
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UniProt Target Context
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Glutaryl-CoA dehydrogenase, mitochondrial |
| UniProt Accession | Q92947 |
| Component Type | Protein |
| Sequence Length | 438 aa |
Glutaryl-CoA dehydrogenase, mitochondrial
How to read this target
Review this target as Glutaryl-CoA dehydrogenase, mitochondrial, mapped to UniProt Q92947. Sequence length is 438 aa.
Clinical Phase Distribution
Activity Type Distribution
Top Inhibitors (by pChEMBL)
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5653589 | 6.83 | Kd | 148.38 | Preclinical |
| CHEMBL3752910 | 5.19 | Kd | 6479.58 | Preclinical |
| CHEMBL1201346 | 4.76 | EC50 | 17300.0 | Approved |
| CHEMBL5176252 | 4.3 | EC50 | 50200.0 | Preclinical |
| CHEMBL5204662 | 4.22 | EC50 | 59500.0 | Preclinical |
pChEMBL Value Distribution
Assay Landscape
Binding — 3 assays, 5 compounds
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| subcellular format | 2 | 3 | 4.4 |
| single protein format | 1 | 2 | 6.0 |
ADME — 1 assays, 0 compounds
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 1 | 0 | — |