Lysophosphatidic acid receptor 1 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Lysophosphatidic acid receptor 1 shows clinical signal disease relevance led by idiopathic pulmonary fibrosis. 1 more disease program remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt Q92633. Start with idiopathic pulmonary fibrosis, then reuse UniProt Q92633 as the stable protein anchor across project notes and exports.
Start with idiopathic pulmonary fibrosis, then reuse UniProt Q92633 as the stable protein anchor across project notes and exports.
Lysophosphatidic acid receptor 1 shows clinical signal disease relevance led by idiopathic pulmonary fibrosis. 1 more disease program remain visible in the same review block. 1 linked drug remains visible in the same block.
Start review with idiopathic pulmonary fibrosis because it currently carries clinical signal support. Linked drugs include BMS-986020. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyLysophosphatidic acid receptor 1
Review this target as Lysophosphatidic acid receptor 1, mapped to UniProt Q92633. Sequence length is 364 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Lysophosphatidic acid receptor 1 as ChEMBL target CHEMBL3819, mapped to UniProt Q92633. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Lysophosphatidic acid receptor 1 is the right protein anchor across sources, using UniProt Q92633 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why idiopathic pulmonary fibrosis is currently framed as clinical signal support. It currently carries 1 linked drug in the same disease frame.
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| Preferred Name | Lysophosphatidic acid receptor 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q92633 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Lysophosphatidic acid receptor 1 |
| UniProt Accession | Q92633 |
| Component Type | Protein |
| Sequence Length | 364 aa |
Lysophosphatidic acid receptor 1
Review this target as Lysophosphatidic acid receptor 1, mapped to UniProt Q92633. Sequence length is 364 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Lysophosphatidic acid receptor 1 shows clinical signal disease relevance led by idiopathic pulmonary fibrosis. 1 more disease program remain visible in the same review block.
Start review with idiopathic pulmonary fibrosis because it currently carries clinical signal support. Linked drugs include BMS-986020. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4165205 | 9.8 | IC50 | 0.16 | Preclinical |
| CHEMBL3966526 | 9.52 | IC50 | 0.3 | Preclinical |
| CHEMBL4175820 | 9.47 | Kd | 0.34 | Preclinical |
| CHEMBL3943133 | 9.4 | IC50 | 0.4 | Preclinical |
| CHEMBL3936755 | 9.4 | IC50 | 0.4 | Preclinical |
| CHEMBL3980736 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL3972698 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL5566408 | 8.85 | IC50 | 1.4 | Preclinical |
| CHEMBL5633614 | 8.8 | IC50 | 1.6 | Preclinical |
| CHEMBL3911605 | 8.7 | IC50 | 2.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 62 | 294 | 6.5 |
| single protein format | 4 | 13 | 6.9 |
| assay format | 3 | 16 | 6.9 |
| tissue-based format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 22 | 146 | 7.5 |
| single protein format | 12 | 28 | 6.7 |
| assay format | 1 | 18 | 7.4 |
| cell-free format | 1 | 1 | 7.3 |