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Target Snapshot

CHEMBL3825 Target Snapshot

Penicillin-binding protein 2 · SINGLE PROTEIN · Staphylococcus aureus

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28Compounds
12Assays
0Approved Drugs
35.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Penicillin-binding protein 2 shows approved-linked disease relevance led by bacteriemia. 5 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt Q53729. Start with bacteriemia, then reuse UniProt Q53729 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with bacteriemia, then reuse UniProt Q53729 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13 1 linked drug
Open source guide
Disease program
bacteriemia

Penicillin-binding protein 2 shows approved-linked disease relevance led by bacteriemia. 5 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.

Start review with bacteriemia because it currently carries approved-linked support. Linked drugs include CEFTOBIPROLE MEDOCARIL SODIUM. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Approved-linked Open Targets-ready proxy 1 linked drug
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Penicillin-binding protein 2 as ChEMBL target CHEMBL3825, mapped to UniProt Q53729. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Penicillin-binding protein 2
SINGLE PROTEIN · Staphylococcus aureus
As of 2026-09-13
ChEMBL target ID
CHEMBL3825
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q53729
Penicillin-binding protein 2
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Penicillin-binding protein 2 is the right protein anchor across sources, using UniProt Q53729 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why bacteriemia is currently framed as approved-linked support. It currently carries 1 linked drug in the same disease frame.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NamePenicillin-binding protein 2
Target TypeSINGLE PROTEIN
OrganismStaphylococcus aureus
UniProtQ53729
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelPenicillin-binding protein 2
UniProt AccessionQ53729
Component TypeProtein
Sequence Length716 aa

Penicillin-binding protein 2

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Penicillin-binding protein 2, mapped to UniProt Q53729. Sequence length is 716 aa.

Mapped IDQ53729
Review namePenicillin-binding protein 2
OrganismStaphylococcus aureus
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Approved-linked Open Targets-ready proxy

Penicillin-binding protein 2 shows approved-linked disease relevance led by bacteriemia. 5 more disease programs remain visible in the same review block.

Approved-linked Approved
bacteriemia
1 linked drug · 1 direct · 1 efficacy
Linked drugCEFTOBIPROLE MEDOCARIL SODIUM
Approved-linked Approved
infective endocarditis
1 linked drug · 1 direct · 1 efficacy
Linked drugCEFTOBIPROLE MEDOCARIL SODIUM
Approved-linked Approved
skin disease caused by bacterial infection
1 linked drug · 1 direct · 1 efficacy
Linked drugCEFTOBIPROLE MEDOCARIL SODIUM
Late clinical Phase III
infection
1 linked drug · 1 direct · 1 efficacy
Linked drugCEFTOBIPROLE MEDOCARIL SODIUM
Late clinical Phase III
Neonatal sepsis
1 linked drug · 1 direct · 1 efficacy
Linked drugCEFTOBIPROLE MEDOCARIL SODIUM
Late clinical Phase III
pneumonia
1 linked drug · 1 direct · 1 efficacy
Linked drugCEFTOBIPROLE MEDOCARIL SODIUM
Source · ChEMBL drug mechanism + indication proxy
ChEMBL target record ↗
Review Cue

How to read disease relevance

Start review with bacteriemia because it currently carries approved-linked support. Linked drugs include CEFTOBIPROLE MEDOCARIL SODIUM. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseasebacteriemia
Strongest levelApproved-linked
Block modeOpen Targets-ready proxy
Assay Mix

Activity Type Distribution

IC5035.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL123481 5.41 IC50 3900.0 Preclinical
CHEMBL6461 5.3 IC50 5000.0 Preclinical
CHEMBL332565 4.85 IC50 14100.0 Preclinical
CHEMBL3746902 4.68 IC50 20700.0 Preclinical
CHEMBL333330 4.55 IC50 28000.0 Preclinical
CHEMBL121924 4.48 IC50 33000.0 Preclinical
Distribution

pChEMBL Value Distribution

4
5.0
0
5.5
0
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

12
Total Assays
6
Tested Compounds
1
Assay Types
Binding — 12 assays, 6 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 12 6 4.7

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine