P2X2/P2X3 heterotrimeric receptor · PROTEIN COMPLEX · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt Q9UBL9. Use UniProt Q9UBL9 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q9UBL9 as the stable identity anchor, then attach disease evidence before program review.
P2X purinoceptor 2
Review this target as P2X2/P2X3 heterotrimeric receptor, mapped to UniProt Q9UBL9. ChEMBL maps the protein component as P2X purinoceptor 2. Sequence length is 471 aa.
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This review treats P2X2/P2X3 heterotrimeric receptor as ChEMBL target CHEMBL3831281, mapped to UniProt Q9UBL9. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | P2X2/P2X3 heterotrimeric receptor |
| Target Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
| UniProt | Q9UBL9 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | P2X purinoceptor 2 |
| UniProt Accession | Q9UBL9 |
| Component Type | Protein |
| Sequence Length | 471 aa |
P2X purinoceptor 2
Review this target as P2X2/P2X3 heterotrimeric receptor, mapped to UniProt Q9UBL9. ChEMBL maps the protein component as P2X purinoceptor 2. Sequence length is 471 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3715500 | 8.42 | Ki | 3.802 | Preclinical |
| CHEMBL494161 | 8.3 | IC50 | 5.012 | Preclinical |
| CHEMBL3727382 | 8.22 | IC50 | 6.0 | Preclinical |
| CHEMBL3731764 | 8.15 | IC50 | 7.0 | Preclinical |
| CHEMBL3730477 | 8.15 | IC50 | 7.0 | Preclinical |
| CHEMBL494161 | 8.1 | Ki | 7.943 | Preclinical |
| CHEMBL4583478 | 8.08 | IC50 | 8.318 | Preclinical |
| CHEMBL3732909 | 8.05 | IC50 | 9.0 | Preclinical |
| CHEMBL596234 | 8.05 | Ki | 9.0 | Preclinical |
| CHEMBL3732768 | 8.0 | IC50 | 10.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 12 | 458 | 6.3 |
| protein complex format | 9 | 8 | 6.0 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 17 | 229 | 6.9 |
| assay format | 1 | 0 | — |