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Target Snapshot

CHEMBL3832741 Target Snapshot

dsDNA · NUCLEIC-ACID · Homo sapiens

314Compounds
149Assays
2Approved Drugs
101.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats dsDNA as ChEMBL target CHEMBL3832741. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
dsDNA
NUCLEIC-ACID · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL3832741
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether dsDNA still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabeldsDNA
UniProt AccessionN/A

dsDNA

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as dsDNA.

Review namedsDNA
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

2
Approved
1
Phase II
Assay Mix

Activity Type Distribution

EC5056.0
KD45.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5276924 8.08 Kd 8.28 Preclinical
CHEMBL5268128 7.3 Kd 49.9 Preclinical
CHEMBL295124 7.0 EC50 100.0 Approved
CHEMBL5594821 6.66 EC50 220.0 Preclinical
CHEMBL4459668 6.57 Kd 270.0 Preclinical
CHEMBL5183480 6.46 Kd 346.0 Preclinical
CHEMBL5593587 6.46 EC50 350.0 Preclinical
CHEMBL5182279 6.44 Kd 366.0 Preclinical
CHEMBL4455539 6.42 Kd 380.0 Preclinical
CHEMBL5174777 6.42 Kd 376.0 Preclinical
Distribution

pChEMBL Value Distribution

20
5.0
23
5.5
25
6.0
6
6.5
2
7.0
0
7.5
1
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

Assay Landscape

Assay Landscape

149
Total Assays
46
Tested Compounds
2
Assay Types
Binding — 144 assays, 46 compounds
BAO Format Assays Compounds Avg pChEMBL
nucleic acid format 141 46 5.7
cell-based format 3 0
Functional — 5 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 5 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine