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Target Snapshot

CHEMBL3832742 Target Snapshot

quadruplex DNA · NUCLEIC-ACID · Homo sapiens

Back to Search Search this target Browse approvals Evidence Card
718Compounds
1,257Assays
2Approved Drugs
438.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats quadruplex DNA as ChEMBL target CHEMBL3832742. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
quadruplex DNA
NUCLEIC-ACID · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL3832742
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether quadruplex DNA still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred Namequadruplex DNA
Target TypeNUCLEIC-ACID
OrganismHomo sapiens
ChEMBL ↗ NCBI Nucleotide ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein Labelquadruplex DNA
UniProt AccessionN/A

quadruplex DNA

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as quadruplex DNA.

Review namequadruplex DNA
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

2
Approved
3
Phase II
1
Phase I
Assay Mix

Activity Type Distribution

IC5013.0
KI5.0
EC504.0
KD416.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL2335138 8.7 Kd 2.0 Preclinical
CHEMBL4640542 8.7 Kd 2.0 Preclinical
CHEMBL4103012 8.52 Kd 3.0 Preclinical
CHEMBL5589886 8.28 Kd 5.3 Preclinical
CHEMBL5594821 8.0 Kd 10.0 Preclinical
CHEMBL4468209 7.75 Kd 17.9 Preclinical
CHEMBL5560285 7.7 Kd 20.0 Preclinical
CHEMBL4526946 7.67 Kd 21.4 Preclinical
CHEMBL5177572 7.52 Kd 30.0 Preclinical
CHEMBL5563598 7.52 Kd 30.0 Preclinical
Distribution

pChEMBL Value Distribution

74
5.0
85
5.5
53
6.0
50
6.5
34
7.0
10
7.5
8
8.0
6
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

METHYLENE BLUE ANHYDROUS
CHEMBL405110
Approved 2011
Properties Compare Identifier
Assay Landscape

Assay Landscape

1,257
Total Assays
174
Tested Compounds
3
Assay Types
Binding — 1,229 assays, 174 compounds
BAO Format Assays Compounds Avg pChEMBL
nucleic acid format 1,095 174 6.0
cell-based format 130 0 —
assay format 3 0 —
mitochondrion format 1 0 —
Functional — 21 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 19 0 —
cell-based format 2 0 —
ADME — 7 assays, 1 compounds
BAO Format Assays Compounds Avg pChEMBL
nucleic acid format 7 1 4.7

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine