Histone deacetylase · PROTEIN FAMILY · Mus musculus
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As of 2026-09-14Protein identity stays anchored to UniProt Q8VH37. Use UniProt Q8VH37 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q8VH37 as the stable identity anchor, then attach disease evidence before program review.
Histone deacetylase 8
Review this target as Histone deacetylase, mapped to UniProt Q8VH37. ChEMBL maps the protein component as Histone deacetylase 8. Sequence length is 377 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Histone deacetylase as ChEMBL target CHEMBL3832944, mapped to UniProt Q8VH37. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Histone deacetylase is the right protein anchor across sources, using UniProt Q8VH37 as the stable mapping.
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| Preferred Name | Histone deacetylase |
| Target Type | PROTEIN FAMILY |
| Organism | Mus musculus |
| UniProt | Q8VH37 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Histone deacetylase 8 |
| UniProt Accession | Q8VH37 |
| Component Type | Protein |
| Sequence Length | 377 aa |
Histone deacetylase 8
Review this target as Histone deacetylase, mapped to UniProt Q8VH37. ChEMBL maps the protein component as Histone deacetylase 8. Sequence length is 377 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL99 | 8.84 | IC50 | 1.44 | Preclinical |
| CHEMBL4439518 | 8.82 | IC50 | 1.5 | Preclinical |
| CHEMBL1790595 | 8.4 | IC50 | 3.96 | Preclinical |
| CHEMBL314389 | 7.8 | IC50 | 15.7 | Preclinical |
| CHEMBL4447524 | 7.55 | IC50 | 28.0 | Preclinical |
| CHEMBL1790586 | 7.08 | IC50 | 84.0 | Preclinical |
| CHEMBL1790590 | 6.85 | IC50 | 141.0 | Preclinical |
| CHEMBL1790604 | 6.02 | IC50 | 957.0 | Preclinical |
| CHEMBL1790598 | 5.87 | IC50 | 1350.0 | Preclinical |
| CHEMBL1790584 | 5.86 | IC50 | 1392.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 23 | 10 | 5.7 |
| assay format | 1 | 2 | 8.2 |
| protein format | 1 | 2 | 8.3 |