LIM domain kinase 1 · SINGLE PROTEIN · Homo sapiens
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Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-13Protein identity stays anchored to UniProt P53667. Use UniProt P53667 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P53667 as the stable identity anchor, then attach disease evidence before program review.
LIM domain kinase 1
Review this target as LIM domain kinase 1, mapped to UniProt P53667. Sequence length is 647 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats LIM domain kinase 1 as ChEMBL target CHEMBL3836, mapped to UniProt P53667. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether LIM domain kinase 1 is the right protein anchor across sources, using UniProt P53667 as the stable mapping.
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| Preferred Name | LIM domain kinase 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P53667 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | LIM domain kinase 1 |
| UniProt Accession | P53667 |
| Component Type | Protein |
| Sequence Length | 647 aa |
LIM domain kinase 1
Review this target as LIM domain kinase 1, mapped to UniProt P53667. Sequence length is 647 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3623439 | 9.52 | IC50 | 0.3 | Preclinical |
| CHEMBL5278261 | 9.52 | IC50 | 0.3 | Preclinical |
| CHEMBL570126 | 9.3 | IC50 | 0.5 | Preclinical |
| CHEMBL2070615 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL3623442 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL5275331 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL5169387 | 8.84 | IC50 | 1.445 | Preclinical |
| CHEMBL3218297 | 8.76 | IC50 | 1.74 | Preclinical |
| CHEMBL570116 | 8.7 | IC50 | 1.995 | Preclinical |
| CHEMBL388978 | 8.61 | IC50 | 2.44 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 225 | 300 | 6.6 |
| cell-based format | 29 | 68 | 6.8 |
| assay format | 28 | 4 | 7.2 |
| subcellular format | 7 | 27 | 6.1 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 346 | 5.8 |