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Target Snapshot

CHEMBL3837 Target Snapshot

Procathepsin L · SINGLE PROTEIN · Homo sapiens

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3,491Compounds
473Assays
2Approved Drugs
3,181.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt P07711. Use UniProt P07711 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P07711 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Procathepsin L as ChEMBL target CHEMBL3837, mapped to UniProt P07711. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Procathepsin L
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL3837
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P07711
Procathepsin L
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Procathepsin L is the right protein anchor across sources, using UniProt P07711 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameProcathepsin L
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtP07711
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelProcathepsin L
UniProt AccessionP07711
Component TypeProtein
Sequence Length333 aa

Procathepsin L

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Procathepsin L, mapped to UniProt P07711. Sequence length is 333 aa.

Mapped IDP07711
Review nameProcathepsin L
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

2
Approved
3
Phase III
10
Phase II
Assay Mix

Activity Type Distribution

IC502,040.0
KI1,140.0
EC501.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL190121 10.6 Ki 0.025 Preclinical
CHEMBL191558 10.44 Ki 0.036 Preclinical
CHEMBL202668 10.4 Ki 0.04 Preclinical
CHEMBL1651355 10.35 Ki 0.045 Preclinical
CHEMBL286722 10.31 Ki 0.049 Preclinical
CHEMBL304784 10.19 Ki 0.0645 Preclinical
CHEMBL203665 10.17 Ki 0.068 Clinical
CHEMBL4441303 10.03 IC50 0.094 Preclinical
CHEMBL287630 10.0 IC50 0.1 Preclinical
CHEMBL31788 10.0 IC50 0.1 Preclinical
Distribution

pChEMBL Value Distribution

269
5.0
323
5.5
322
6.0
274
6.5
233
7.0
198
7.5
185
8.0
88
8.5
52
9.0
9
9.5
pChEMBL
Approved Drugs

Approved Drugs

BOCEPREVIR
CHEMBL218394
Approved 2011
Properties Compare Identifier
Assay Landscape

Assay Landscape

475
Total Assays
2,029
Tested Compounds
4
Assay Types
Binding — 451 assays, 2,029 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 354 1,766 6.6
assay format 74 236 6.0
cell-based format 15 10 6.6
tissue-based format 7 17 7.0
subcellular format 1 0 —
ADME — 11 assays, 47 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 11 47 7.0
Functional — 8 assays, 4 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 5 4 8.1
tissue-based format 3 0 —
Toxicity — 5 assays, 10 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 5 10 7.1

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine