Ribonucleoside-diphosphate reductase large subunit · SINGLE PROTEIN · Herpes simplex virus (type 1 / strain 17)
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As of 2026-09-14Protein identity stays anchored to UniProt P08543. Use UniProt P08543 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P08543 as the stable identity anchor, then attach disease evidence before program review.
Ribonucleoside-diphosphate reductase large subunit
Review this target as Ribonucleoside-diphosphate reductase large subunit, mapped to UniProt P08543. Sequence length is 1137 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Ribonucleoside-diphosphate reductase large subunit as ChEMBL target CHEMBL3840, mapped to UniProt P08543. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Ribonucleoside-diphosphate reductase large subunit |
| Target Type | SINGLE PROTEIN |
| Organism | Herpes simplex virus (type 1 / strain 17) |
| UniProt | P08543 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Ribonucleoside-diphosphate reductase large subunit |
| UniProt Accession | P08543 |
| Component Type | Protein |
| Sequence Length | 1137 aa |
Ribonucleoside-diphosphate reductase large subunit
Review this target as Ribonucleoside-diphosphate reductase large subunit, mapped to UniProt P08543. Sequence length is 1137 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL305199 | 8.52 | IC50 | 3.0 | Preclinical |
| CHEMBL70278 | 8.3 | IC50 | 5.0 | Preclinical |
| CHEMBL37210 | 8.15 | IC50 | 7.0 | Preclinical |
| CHEMBL420185 | 8.0 | IC50 | 10.0 | Preclinical |
| CHEMBL71945 | 7.82 | IC50 | 15.0 | Preclinical |
| CHEMBL305229 | 7.62 | IC50 | 24.0 | Preclinical |
| CHEMBL70879 | 7.5 | IC50 | 32.0 | Preclinical |
| CHEMBL2369478 | 7.46 | IC50 | 35.0 | Preclinical |
| CHEMBL2369482 | 6.97 | IC50 | 108.0 | Preclinical |
| CHEMBL267068 | 6.85 | IC50 | 140.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 3 | 63 | 4.9 |