Aromatase · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-14Protein identity stays anchored to UniProt P22443. Use UniProt P22443 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P22443 as the stable identity anchor, then attach disease evidence before program review.
Aromatase
Review this target as Aromatase, mapped to UniProt P22443. Sequence length is 508 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Aromatase as ChEMBL target CHEMBL3859, mapped to UniProt P22443. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Aromatase is the right protein anchor across sources, using UniProt P22443 as the stable mapping.
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| Preferred Name | Aromatase |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | P22443 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Aromatase |
| UniProt Accession | P22443 |
| Component Type | Protein |
| Sequence Length | 508 aa |
Aromatase
Review this target as Aromatase, mapped to UniProt P22443. Sequence length is 508 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL100749 | 8.52 | IC50 | 3.0 | Preclinical |
| CHEMBL135381 | 8.19 | EC50 | 6.4 | Preclinical |
| CHEMBL135063 | 8.08 | EC50 | 8.4 | Preclinical |
| CHEMBL341386 | 8.06 | EC50 | 8.8 | Preclinical |
| CHEMBL436369 | 8.05 | EC50 | 8.9 | Preclinical |
| CHEMBL135563 | 8.03 | EC50 | 9.3 | Preclinical |
| CHEMBL137604 | 8.03 | EC50 | 9.4 | Preclinical |
| CHEMBL137552 | 8.02 | EC50 | 9.6 | Preclinical |
| CHEMBL335050 | 7.98 | EC50 | 10.5 | Preclinical |
| CHEMBL135595 | 7.97 | EC50 | 10.8 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 16 | 12 | 6.5 |
| assay format | 13 | 87 | 6.8 |
| tissue-based format | 1 | 1 | 7.8 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| organism-based format | 11 | 0 | — |
| assay format | 10 | 0 | — |
| cell-free format | 2 | 0 | — |