G protein-coupled receptor kinase 5 · SINGLE PROTEIN · Bos taurus
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As of 2026-09-14Protein identity stays anchored to UniProt P43249. Use UniProt P43249 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P43249 as the stable identity anchor, then attach disease evidence before program review.
G protein-coupled receptor kinase 5
Review this target as G protein-coupled receptor kinase 5, mapped to UniProt P43249. Sequence length is 590 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats G protein-coupled receptor kinase 5 as ChEMBL target CHEMBL3879830, mapped to UniProt P43249. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | G protein-coupled receptor kinase 5 |
| Target Type | SINGLE PROTEIN |
| Organism | Bos taurus |
| UniProt | P43249 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | G protein-coupled receptor kinase 5 |
| UniProt Accession | P43249 |
| Component Type | Protein |
| Sequence Length | 590 aa |
G protein-coupled receptor kinase 5
Review this target as G protein-coupled receptor kinase 5, mapped to UniProt P43249. Sequence length is 590 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL60254 | 6.36 | IC50 | 440.0 | Preclinical |
| CHEMBL4557065 | 6.16 | IC50 | 700.0 | Preclinical |
| CHEMBL1738878 | 5.66 | IC50 | 2200.0 | Preclinical |
| CHEMBL4097393 | 5.4 | IC50 | 4000.0 | Preclinical |
| CHEMBL4090144 | 5.15 | IC50 | 7090.0 | Preclinical |
| CHEMBL1738877 | 5.04 | IC50 | 9200.0 | Preclinical |
| CHEMBL4064274 | 4.99 | IC50 | 10200.0 | Preclinical |
| CHEMBL4075475 | 4.83 | IC50 | 14800.0 | Preclinical |
| CHEMBL4070885 | 4.77 | IC50 | 17100.0 | Preclinical |
| CHEMBL4063014 | 4.48 | IC50 | 33200.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 8 | 26 | 4.6 |