Thioredoxin reductase · SINGLE PROTEIN · Entamoeba histolytica
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As of 2026-09-13Protein identity stays anchored to UniProt C4LW95. Use UniProt C4LW95 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt C4LW95 as the stable identity anchor, then attach disease evidence before program review.
Thioredoxin reductase
Review this target as Thioredoxin reductase, mapped to UniProt C4LW95. Sequence length is 314 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Thioredoxin reductase as ChEMBL target CHEMBL3879846, mapped to UniProt C4LW95. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Thioredoxin reductase |
| Target Type | SINGLE PROTEIN |
| Organism | Entamoeba histolytica |
| UniProt | C4LW95 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Thioredoxin reductase |
| UniProt Accession | C4LW95 |
| Component Type | Protein |
| Sequence Length | 314 aa |
Thioredoxin reductase
Review this target as Thioredoxin reductase, mapped to UniProt C4LW95. Sequence length is 314 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3926452 | 6.41 | Ki | 390.0 | Preclinical |
| CHEMBL3913125 | 6.17 | Ki | 680.0 | Preclinical |
| CHEMBL3968421 | 6.16 | Ki | 690.0 | Preclinical |
| CHEMBL3976958 | 6.14 | Ki | 730.0 | Preclinical |
| CHEMBL3957420 | 5.98 | Ki | 1050.0 | Preclinical |
| CHEMBL3939464 | 5.68 | Ki | 2070.0 | Preclinical |
| CHEMBL3930972 | 5.55 | Ki | 2820.0 | Preclinical |
| CHEMBL516894 | 5.54 | Ki | 2880.0 | Preclinical |
| CHEMBL3986107 | 5.5 | Ki | 3160.0 | Preclinical |
| CHEMBL137 | 5.48 | Ki | 3300.0 | Approved |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 1 | 18 | 5.5 |