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Target Snapshot

CHEMBL3879870 Target Snapshot

N-acetyltransferase Eis · SINGLE PROTEIN · Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

127Compounds
17Assays
3Approved Drugs
128.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt P9WFK7. Use UniProt P9WFK7 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P9WFK7 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats N-acetyltransferase Eis as ChEMBL target CHEMBL3879870, mapped to UniProt P9WFK7. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
N-acetyltransferase Eis
SINGLE PROTEIN · Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
As of 2026-09-13
ChEMBL target ID
CHEMBL3879870
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P9WFK7
N-acetyltransferase Eis
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether N-acetyltransferase Eis is the right protein anchor across sources, using UniProt P9WFK7 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelN-acetyltransferase Eis
UniProt AccessionP9WFK7
Component TypeProtein
Sequence Length402 aa

N-acetyltransferase Eis

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as N-acetyltransferase Eis, mapped to UniProt P9WFK7. Sequence length is 402 aa.

Mapped IDP9WFK7
Review nameN-acetyltransferase Eis
OrganismMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Clinical Profile

Clinical Phase Distribution

3
Approved
2
Phase III
1
Phase II
Assay Mix

Activity Type Distribution

IC50121.0
KI7.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3931964 9.62 IC50 0.24 Preclinical
CHEMBL3931070 7.82 IC50 15.0 Preclinical
CHEMBL3911185 7.57 IC50 27.0 Preclinical
CHEMBL3963272 7.25 IC50 56.0 Preclinical
CHEMBL3900481 7.1 IC50 80.0 Preclinical
CHEMBL1410785 7.05 IC50 90.0 Preclinical
CHEMBL3909504 7.0 IC50 100.0 Preclinical
CHEMBL5573832 6.82 IC50 150.0 Preclinical
CHEMBL3950034 6.8 IC50 160.0 Preclinical
CHEMBL3967657 6.64 IC50 230.0 Preclinical
Distribution

pChEMBL Value Distribution

21
5.0
22
5.5
15
6.0
9
6.5
4
7.0
2
7.5
0
8.0
0
8.5
0
9.0
1
9.5
pChEMBL
Approved Drugs

Approved Drugs

HALOPERIDOL
CHEMBL54
Approved 1967
Assay Landscape

Assay Landscape

17
Total Assays
85
Tested Compounds
1
Assay Types
Binding — 17 assays, 85 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 13 47 5.7
assay format 2 17 6.1
cell-based format 2 21 5.5

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine