DNA excision repair protein ERCC-1/DNA repair endonuclease XPF · PROTEIN COMPLEX · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P07992. Use UniProt P07992 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P07992 as the stable identity anchor, then attach disease evidence before program review.
DNA excision repair protein ERCC-1
Review this target as DNA excision repair protein ERCC-1/DNA repair endonuclease XPF, mapped to UniProt P07992. ChEMBL maps the protein component as DNA excision repair protein ERCC-1. Sequence length is 297 aa.
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This review treats DNA excision repair protein ERCC-1/DNA repair endonuclease XPF as ChEMBL target CHEMBL3883316, mapped to UniProt P07992. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether DNA excision repair protein ERCC-1/DNA repair endonuclease XPF is the right protein anchor across sources, using UniProt P07992 as the stable mapping.
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| Preferred Name | DNA excision repair protein ERCC-1/DNA repair endonuclease XPF |
| Target Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
| UniProt | P07992 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | DNA excision repair protein ERCC-1 |
| UniProt Accession | P07992 |
| Component Type | Protein |
| Sequence Length | 297 aa |
DNA excision repair protein ERCC-1
Review this target as DNA excision repair protein ERCC-1/DNA repair endonuclease XPF, mapped to UniProt P07992. ChEMBL maps the protein component as DNA excision repair protein ERCC-1. Sequence length is 297 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4759590 | 7.07 | Kd | 85.0 | Preclinical |
| CHEMBL4470176 | 7.0 | Kd | 100.0 | Preclinical |
| CHEMBL463783 | 6.85 | Kd | 140.0 | Preclinical |
| CHEMBL4470176 | 6.48 | IC50 | 330.0 | Preclinical |
| CHEMBL4759590 | 6.31 | IC50 | 490.0 | Preclinical |
| CHEMBL3617281 | 6.3 | IC50 | 500.0 | Preclinical |
| CHEMBL3617205 | 6.22 | IC50 | 600.0 | Preclinical |
| CHEMBL3617209 | 6.22 | IC50 | 600.0 | Preclinical |
| CHEMBL3617002 | 6.2 | IC50 | 630.0 | Preclinical |
| CHEMBL3617207 | 6.16 | IC50 | 700.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 16 | 3 | 6.2 |
| assay format | 6 | 2 | 6.4 |
| protein complex format | 5 | 77 | 5.3 |
| tissue-based format | 1 | 0 | — |