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Target Snapshot

CHEMBL3883321 Target Snapshot

Mu opioid receptor/Alpha-2A adrenergic receptor · PROTEIN COMPLEX · Homo sapiens

2Compounds
9Assays
1Approved Drugs
1.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P08913. Use UniProt P08913 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P08913 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Mu opioid receptor/Alpha-2A adrenergic receptor as ChEMBL target CHEMBL3883321, mapped to UniProt P08913. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Mu opioid receptor/Alpha-2A adrenergic receptor
PROTEIN COMPLEX · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL3883321
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P08913
Alpha-2A adrenergic receptor
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Mu opioid receptor/Alpha-2A adrenergic receptor is the right protein anchor across sources, using UniProt P08913 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelAlpha-2A adrenergic receptor
UniProt AccessionP08913
Component TypeProtein
Sequence Length465 aa

Alpha-2A adrenergic receptor

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Mu opioid receptor/Alpha-2A adrenergic receptor, mapped to UniProt P08913. ChEMBL maps the protein component as Alpha-2A adrenergic receptor. Sequence length is 465 aa.

Mapped IDP08913
Review nameMu opioid receptor/Alpha-2A adrenergic receptor
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

1
Approved
Assay Mix

Activity Type Distribution

EC501.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL70 8.52 EC50 3.0 Approved
Distribution

pChEMBL Value Distribution

0
5.0
0
5.5
0
6.0
0
6.5
0
7.0
0
7.5
0
8.0
1
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

MORPHINE
CHEMBL70
Approved 1984
Assay Landscape

Assay Landscape

9
Total Assays
1
Tested Compounds
1
Assay Types
Binding — 9 assays, 1 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 9 1 8.5

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine