Acetyl-CoA carboxylase · PROTEIN FAMILY · Homo sapiens
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As of 2026-09-14Acetyl-CoA carboxylase shows late clinical disease relevance led by acne. 5 more disease programs remain visible in the same review block. 2 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt Q13085. Start with acne, then reuse UniProt Q13085 as the stable protein anchor across project notes and exports.
Start with acne, then reuse UniProt Q13085 as the stable protein anchor across project notes and exports.
Acetyl-CoA carboxylase shows late clinical disease relevance led by acne. 5 more disease programs remain visible in the same review block. 2 linked drugs remain visible in the same block.
Start review with acne because it currently carries late clinical support. Linked drugs include OLUMACOSTAT GLASARETIL, PF-05175157. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyAcetyl-CoA carboxylase 1
Review this target as Acetyl-CoA carboxylase, mapped to UniProt Q13085. ChEMBL maps the protein component as Acetyl-CoA carboxylase 1. Sequence length is 2346 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Acetyl-CoA carboxylase as ChEMBL target CHEMBL3885507, mapped to UniProt Q13085. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Acetyl-CoA carboxylase is the right protein anchor across sources, using UniProt Q13085 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why acne is currently framed as late clinical support. It currently carries 2 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Acetyl-CoA carboxylase |
| Target Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
| UniProt | Q13085 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Acetyl-CoA carboxylase 1 |
| UniProt Accession | Q13085 |
| Component Type | Protein |
| Sequence Length | 2346 aa |
Acetyl-CoA carboxylase 1
Review this target as Acetyl-CoA carboxylase, mapped to UniProt Q13085. ChEMBL maps the protein component as Acetyl-CoA carboxylase 1. Sequence length is 2346 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Acetyl-CoA carboxylase shows late clinical disease relevance led by acne. 5 more disease programs remain visible in the same review block.
Start review with acne because it currently carries late clinical support. Linked drugs include OLUMACOSTAT GLASARETIL, PF-05175157. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL1170494 | 8.08 | IC50 | 8.4 | Preclinical |
| CHEMBL1170493 | 8.01 | IC50 | 9.7 | Preclinical |
| CHEMBL1683801 | 7.92 | IC50 | 12.0 | Preclinical |
| CHEMBL1683791 | 7.77 | IC50 | 17.0 | Preclinical |
| CHEMBL1170510 | 7.68 | IC50 | 21.0 | Preclinical |
| CHEMBL1683789 | 7.62 | IC50 | 24.0 | Preclinical |
| CHEMBL1170515 | 7.57 | IC50 | 27.0 | Preclinical |
| CHEMBL1683800 | 7.57 | IC50 | 27.0 | Preclinical |
| CHEMBL1683786 | 7.55 | IC50 | 28.0 | Preclinical |
| CHEMBL1170498 | 7.52 | IC50 | 30.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 4 | 0 | — |
| protein format | 4 | 101 | 7.1 |