MCL1-BAK1 complex · PROTEIN COMPLEX · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q07820. Use UniProt Q07820 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q07820 as the stable identity anchor, then attach disease evidence before program review.
Induced myeloid leukemia cell differentiation protein Mcl-1
Review this target as MCL1-BAK1 complex, mapped to UniProt Q07820. ChEMBL maps the protein component as Induced myeloid leukemia cell differentiation protein Mcl-1. Sequence length is 350 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats MCL1-BAK1 complex as ChEMBL target CHEMBL3885523, mapped to UniProt Q07820. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | MCL1-BAK1 complex |
| Target Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
| UniProt | Q07820 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Induced myeloid leukemia cell differentiation protein Mcl-1 |
| UniProt Accession | Q07820 |
| Component Type | Protein |
| Sequence Length | 350 aa |
Induced myeloid leukemia cell differentiation protein Mcl-1
Review this target as MCL1-BAK1 complex, mapped to UniProt Q07820. ChEMBL maps the protein component as Induced myeloid leukemia cell differentiation protein Mcl-1. Sequence length is 350 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4160782 | 6.92 | Ki | 120.0 | Preclinical |
| CHEMBL5198484 | 6.82 | Ki | 153.0 | Preclinical |
| CHEMBL539481 | 6.64 | IC50 | 230.0 | Preclinical |
| CHEMBL605114 | 6.6 | Kd | 250.0 | Preclinical |
| CHEMBL5203189 | 6.55 | IC50 | 280.0 | Preclinical |
| CHEMBL5182721 | 6.21 | IC50 | 620.0 | Preclinical |
| CHEMBL4077940 | 5.75 | Ki | 1790.0 | Preclinical |
| CHEMBL4167501 | 5.54 | Ki | 2900.0 | Preclinical |
| CHEMBL605114 | 5.16 | Ki | 6900.0 | Preclinical |
| CHEMBL5207001 | 5.11 | Ki | 7770.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein complex format | 8 | 15 | 5.5 |
| cell-based format | 3 | 0 | — |