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Target Snapshot

CHEMBL3885528 Target Snapshot

Thymidylate synthase/GAR transformylase/AICAR transformylase · PROTEIN FAMILY · Homo sapiens

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9Compounds
5Assays
2Approved Drugs
8.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P04818. Use UniProt P04818 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P04818 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Thymidylate synthase/GAR transformylase/AICAR transformylase as ChEMBL target CHEMBL3885528, mapped to UniProt P04818. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Thymidylate synthase/GAR transformylase/AICAR transformylase
PROTEIN FAMILY · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL3885528
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P04818
Thymidylate synthase
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Thymidylate synthase/GAR transformylase/AICAR transformylase is the right protein anchor across sources, using UniProt P04818 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NameThymidylate synthase/GAR transformylase/AICAR transformylase
Target TypePROTEIN FAMILY
OrganismHomo sapiens
UniProtP04818
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelThymidylate synthase
UniProt AccessionP04818
Component TypeProtein
Sequence Length313 aa

Thymidylate synthase

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Thymidylate synthase/GAR transformylase/AICAR transformylase, mapped to UniProt P04818. ChEMBL maps the protein component as Thymidylate synthase. Sequence length is 313 aa.

Mapped IDP04818
Review nameThymidylate synthase/GAR transformylase/AICAR transformylase
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

2
Approved
Assay Mix

Activity Type Distribution

IC508.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4177183 10.11 IC50 0.078 Preclinical
CHEMBL4162649 9.85 IC50 0.14 Preclinical
CHEMBL4170578 8.12 IC50 7.5 Preclinical
CHEMBL34259 8.0 IC50 10.0 Approved
CHEMBL4174018 7.37 IC50 43.0 Preclinical
CHEMBL225072 7.16 IC50 70.0 Approved
CHEMBL4163732 7.04 IC50 92.0 Preclinical
CHEMBL4166099 6.97 IC50 107.0 Preclinical
Distribution

pChEMBL Value Distribution

0
5.0
0
5.5
0
6.0
1
6.5
3
7.0
0
7.5
2
8.0
0
8.5
0
9.0
1
9.5
pChEMBL
Approved Drugs

Approved Drugs

PEMETREXED
CHEMBL225072
Approved 2004
Properties Compare Identifier
METHOTREXATE
CHEMBL34259
Approved 1953
Properties Compare Identifier
Assay Landscape

Assay Landscape

5
Total Assays
8
Tested Compounds
1
Assay Types
Binding — 5 assays, 8 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 5 8 8.1

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine