Dual specificity mitogen-activated protein kinase kinase 1/Mitogen-activated protein kinase 1/RAF proto-oncogene serine/threonine-protein kinase · PROTEIN FAMILY · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P28482. Use UniProt P28482 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P28482 as the stable identity anchor, then attach disease evidence before program review.
Mitogen-activated protein kinase 1
Review this target as Dual specificity mitogen-activated protein kinase kinase 1/Mitogen-activated protein kinase 1/RAF proto-oncogene serine/threonine-protein kinase, mapped to UniProt P28482. ChEMBL maps the protein component as Mitogen-activated protein kinase 1. Sequence length is 360 aa.
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This review treats Dual specificity mitogen-activated protein kinase kinase 1/Mitogen-activated protein kinase 1/RAF proto-oncogene serine/threonine-protein kinase as ChEMBL target CHEMBL3885566, mapped to UniProt P28482. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Dual specificity mitogen-activated protein kinase kinase 1/Mitogen-activated protein kinase 1/RAF proto-oncogene serine/threonine-protein kinase |
| Target Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
| UniProt | P28482 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Mitogen-activated protein kinase 1 |
| UniProt Accession | P28482 |
| Component Type | Protein |
| Sequence Length | 360 aa |
Mitogen-activated protein kinase 1
Review this target as Dual specificity mitogen-activated protein kinase kinase 1/Mitogen-activated protein kinase 1/RAF proto-oncogene serine/threonine-protein kinase, mapped to UniProt P28482. ChEMBL maps the protein component as Mitogen-activated protein kinase 1. Sequence length is 360 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL2152253 | 5.69 | IC50 | 2043.0 | Preclinical |
| CHEMBL2152252 | 5.64 | IC50 | 2313.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein format | 1 | 2 | 5.7 |