Review anchor
Histone deacetylase 2/Nuclear receptor corepressor 2
PROTEIN COMPLEX · Homo sapiens
As of 2026-09-13
Evidence Snapshot
Histone deacetylase 2/Nuclear receptor corepressor 2
CHEMBL3885591
PROTEIN COMPLEX
Homo sapiens
Identity Layer
Cross-source identity
Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Histone deacetylase 2/Nuclear receptor corepressor 2 as ChEMBL target CHEMBL3885591, mapped to UniProt Q92769. Disease framing currently uses the Open Targets-ready proxy contract.
ChEMBL target ID
CHEMBL3885591
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine
As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q92769
Histone deacetylase 2
UniProt accession via ChEMBL component mapping
As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy
As of 2026-09-13
www.ebi.ac.uk
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Review-ready Target Rationale
Why Histone deacetylase 2/Nuclear receptor corepressor 2 matters
Histone deacetylase 2/Nuclear receptor corepressor 2 is reviewed as Histone deacetylase 2 (UniProt Q92769); the current evidence base includes 1 approved drug, 6 compounds, and 1 assay, with lead potency reaching pChEMBL 8.5.
Protein context
Histone deacetylase 2
Histone deacetylase 2 Sequence length is 488 aa.
Review this target as Histone deacetylase 2/Nuclear receptor corepressor 2, mapped to UniProt Q92769. ChEMBL maps the protein component as Histone deacetylase 2. Sequence length is 488 aa.
Protein source · UniProt accession via ChEMBL component mapping
UniProt Q92769
Protein
Disease context
Disease signal
Disease relevance is not yet populated for this evidence card.
This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
ChEMBL target recordActivity base
Portfolio and assay base
ChEMBL currently tracks 1 approved drug, 6 compounds, and 1 assay for this target. The dominant activity type is IC50. CHEMBL1836144 is the current potency anchor at pChEMBL 8.5.
Use CHEMBL1836144 as the tractability anchor when discussing potency (pChEMBL 8.5).
Activity source · ChEMBL 36 via Core Engine
1 approved
pChEMBL 8.5
Source Guidance
Start with the right source
Pick the first block or linked source that matches the review question in front of you.
Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution
Start with the review rationale when you need to explain why Histone deacetylase 2/Nuclear receptor corepressor 2 matters before drilling into raw source blocks.
Jump to Review RationaleNeed stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping
Go back to the target snapshot when you need the naming and mapping contract behind UniProt Q92769, not just the summarized rationale.
Open Protein ContextNeed disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy
Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.
Open Disease ContextSnapshot State
No project snapshot selected. Export uses the live evidence card state.
6
Total Compounds
1
Total Assays
1
Approved Drugs
IC50: 6.0
Activity Types
pChEMBL Activity Distribution
Top 5 Inhibitors (by pChEMBL)
| Structure | Compound | pChEMBL | Type | Phase |
|---|---|---|---|---|
|
|
No preferred name
CHEMBL1836144
|
8.5 | IC50 | — |
|
|
No preferred name
CHEMBL146250
|
8.4 | IC50 | — |
|
|
No preferred name
CHEMBL1836042
|
8.2 | IC50 | — |
|
|
No preferred name
CHEMBL343448
|
5.8 | IC50 | Approved |
|
|
No preferred name
CHEMBL1836145
|
5.3 | IC50 | — |
Source Header