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Target Snapshot

CHEMBL3885593 Target Snapshot

Histone-lysine N-methyltransferase EHMT1/EHMT2 · PROTEIN FAMILY · Homo sapiens

10Compounds
12Assays
0Approved Drugs
1.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q9H9B1. Use UniProt Q9H9B1 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q9H9B1 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Protein anchor
Histone-lysine N-methyltransferase EHMT1

Histone-lysine N-methyltransferase EHMT1

Review this target as Histone-lysine N-methyltransferase EHMT1/EHMT2, mapped to UniProt Q9H9B1. ChEMBL maps the protein component as Histone-lysine N-methyltransferase EHMT1. Sequence length is 1298 aa.

Protein source · UniProt accession via ChEMBL component mapping
UniProt Q9H9B1 Protein 1298 aa
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Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Histone-lysine N-methyltransferase EHMT1/EHMT2 as ChEMBL target CHEMBL3885593, mapped to UniProt Q9H9B1. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Histone-lysine N-methyltransferase EHMT1/EHMT2
PROTEIN FAMILY · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL3885593
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q9H9B1
Histone-lysine N-methyltransferase EHMT1
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Histone-lysine N-methyltransferase EHMT1/EHMT2 is the right protein anchor across sources, using UniProt Q9H9B1 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelHistone-lysine N-methyltransferase EHMT1
UniProt AccessionQ9H9B1
Component TypeProtein
Sequence Length1298 aa

Histone-lysine N-methyltransferase EHMT1

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Histone-lysine N-methyltransferase EHMT1/EHMT2, mapped to UniProt Q9H9B1. ChEMBL maps the protein component as Histone-lysine N-methyltransferase EHMT1. Sequence length is 1298 aa.

Mapped IDQ9H9B1
Review nameHistone-lysine N-methyltransferase EHMT1/EHMT2
OrganismHomo sapiens
Assay Mix

Activity Type Distribution

IC501.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL1231795 7.09 IC50 81.0 Preclinical
Distribution

pChEMBL Value Distribution

0
5.0
0
5.5
0
6.0
0
6.5
1
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

12
Total Assays
1
Tested Compounds
1
Assay Types
Binding — 12 assays, 1 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 11 1 7.1
protein format 1 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine