Integrin alpha-5/Neuronal acetylcholine receptor subunit alpha-3/Neuronal acetylcholine receptor subunit beta-2/Neuronal acetylcholine receptor subunit beta-4 · PROTEIN COMPLEX · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P17787. Use UniProt P17787 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P17787 as the stable identity anchor, then attach disease evidence before program review.
Neuronal acetylcholine receptor subunit beta-2
Review this target as Integrin alpha-5/Neuronal acetylcholine receptor subunit alpha-3/Neuronal acetylcholine receptor subunit beta-2/Neuronal acetylcholine receptor subunit beta-4, mapped to UniProt P17787. ChEMBL maps the protein component as Neuronal acetylcholine receptor subunit beta-2. Sequence length is 502 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Integrin alpha-5/Neuronal acetylcholine receptor subunit alpha-3/Neuronal acetylcholine receptor subunit beta-2/Neuronal acetylcholine receptor subunit beta-4 as ChEMBL target CHEMBL3885595, mapped to UniProt P17787. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Integrin alpha-5/Neuronal acetylcholine receptor subunit alpha-3/Neuronal acetylcholine receptor subunit beta-2/Neuronal acetylcholine receptor subunit beta-4 is the right protein anchor across sources, using UniProt P17787 as the stable mapping.
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| Preferred Name | Integrin alpha-5/Neuronal acetylcholine receptor subunit alpha-3/Neuronal acetylcholine receptor subunit beta-2/Neuronal acetylcholine receptor subunit beta-4 |
| Target Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
| UniProt | P17787 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Neuronal acetylcholine receptor subunit beta-2 |
| UniProt Accession | P17787 |
| Component Type | Protein |
| Sequence Length | 502 aa |
Neuronal acetylcholine receptor subunit beta-2
Review this target as Integrin alpha-5/Neuronal acetylcholine receptor subunit alpha-3/Neuronal acetylcholine receptor subunit beta-2/Neuronal acetylcholine receptor subunit beta-4, mapped to UniProt P17787. ChEMBL maps the protein component as Neuronal acetylcholine receptor subunit beta-2. Sequence length is 502 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL1812744 | 6.24 | IC50 | 570.0 | Preclinical |
| CHEMBL1812747 | 6.14 | IC50 | 730.0 | Preclinical |
| CHEMBL1812740 | 5.89 | IC50 | 1300.0 | Preclinical |
| CHEMBL1812748 | 5.85 | IC50 | 1400.0 | Preclinical |
| CHEMBL1812741 | 5.77 | IC50 | 1700.0 | Preclinical |
| CHEMBL1812739 | 5.75 | IC50 | 1800.0 | Preclinical |
| CHEMBL1812743 | 5.75 | IC50 | 1800.0 | Preclinical |
| CHEMBL894 | 5.75 | IC50 | 1800.0 | Approved |
| CHEMBL1812750 | 5.58 | IC50 | 2600.0 | Preclinical |
| CHEMBL1812746 | 5.51 | IC50 | 3100.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 2 | 13 | 5.7 |