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Target Snapshot

CHEMBL3885636 Target Snapshot

Serine/threonine-protein kinase PAK 1/PAK 2 · PROTEIN FAMILY · Homo sapiens

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18Compounds
1Assays
0Approved Drugs
18.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q13177. Use UniProt Q13177 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q13177 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Serine/threonine-protein kinase PAK 1/PAK 2 as ChEMBL target CHEMBL3885636, mapped to UniProt Q13177. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Serine/threonine-protein kinase PAK 1/PAK 2
PROTEIN FAMILY · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL3885636
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q13177
Serine/threonine-protein kinase PAK 2
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Serine/threonine-protein kinase PAK 1/PAK 2 is the right protein anchor across sources, using UniProt Q13177 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NameSerine/threonine-protein kinase PAK 1/PAK 2
Target TypePROTEIN FAMILY
OrganismHomo sapiens
UniProtQ13177
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelSerine/threonine-protein kinase PAK 2
UniProt AccessionQ13177
Component TypeProtein
Sequence Length524 aa

Serine/threonine-protein kinase PAK 2

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Serine/threonine-protein kinase PAK 1/PAK 2, mapped to UniProt Q13177. ChEMBL maps the protein component as Serine/threonine-protein kinase PAK 2. Sequence length is 524 aa.

Mapped IDQ13177
Review nameSerine/threonine-protein kinase PAK 1/PAK 2
OrganismHomo sapiens
Assay Mix

Activity Type Distribution

IC5018.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3818265 7.48 IC50 33.0 Preclinical
CHEMBL3770443 7.15 IC50 71.0 Preclinical
CHEMBL3817856 7.11 IC50 78.0 Preclinical
CHEMBL3818828 7.06 IC50 88.0 Preclinical
CHEMBL3817984 6.82 IC50 150.0 Preclinical
CHEMBL3770186 6.66 IC50 220.0 Preclinical
CHEMBL3819118 6.62 IC50 240.0 Preclinical
CHEMBL3818479 6.55 IC50 280.0 Preclinical
CHEMBL3818016 6.54 IC50 290.0 Preclinical
CHEMBL3817890 6.47 IC50 340.0 Preclinical
Distribution

pChEMBL Value Distribution

1
5.0
0
5.5
6
6.0
5
6.5
4
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

1
Total Assays
17
Tested Compounds
1
Assay Types
Binding — 1 assays, 17 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 17 6.4

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine