Toll-like receptor 1/2 · PROTEIN COMPLEX · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt O60603. Use UniProt O60603 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt O60603 as the stable identity anchor, then attach disease evidence before program review.
Toll-like receptor 2
Review this target as Toll-like receptor 1/2, mapped to UniProt O60603. ChEMBL maps the protein component as Toll-like receptor 2. Sequence length is 784 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Toll-like receptor 1/2 as ChEMBL target CHEMBL3885643, mapped to UniProt O60603. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Toll-like receptor 1/2 is the right protein anchor across sources, using UniProt O60603 as the stable mapping.
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| Preferred Name | Toll-like receptor 1/2 |
| Target Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
| UniProt | O60603 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Toll-like receptor 2 |
| UniProt Accession | O60603 |
| Component Type | Protein |
| Sequence Length | 784 aa |
Toll-like receptor 2
Review this target as Toll-like receptor 1/2, mapped to UniProt O60603. ChEMBL maps the protein component as Toll-like receptor 2. Sequence length is 784 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5179849 | 10.4 | EC50 | 0.04 | Preclinical |
| CHEMBL5195088 | 10.3 | EC50 | 0.05 | Preclinical |
| CHEMBL5202312 | 10.3 | EC50 | 0.05 | Preclinical |
| CHEMBL5208283 | 10.22 | EC50 | 0.06 | Preclinical |
| CHEMBL5179644 | 10.15 | EC50 | 0.07 | Preclinical |
| CHEMBL5205616 | 10.15 | EC50 | 0.07 | Preclinical |
| CHEMBL5279981 | 10.1 | EC50 | 0.08 | Preclinical |
| CHEMBL5169846 | 10.0 | EC50 | 0.1 | Preclinical |
| CHEMBL5185917 | 10.0 | EC50 | 0.1 | Preclinical |
| CHEMBL5187007 | 10.0 | EC50 | 0.1 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 43 | 144 | 8.2 |
| protein complex format | 6 | 18 | 6.8 |