Voltage-dependent L-type calcium channel subunit beta-1/alpha-1B/alpha-2/delta-1 · PROTEIN COMPLEX · Rattus norvegicus
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As of 2026-09-14Protein identity stays anchored to UniProt P54290. Use UniProt P54290 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P54290 as the stable identity anchor, then attach disease evidence before program review.
Voltage-dependent calcium channel subunit alpha-2/delta-1
Review this target as Voltage-dependent L-type calcium channel subunit beta-1/alpha-1B/alpha-2/delta-1, mapped to UniProt P54290. ChEMBL maps the protein component as Voltage-dependent calcium channel subunit alpha-2/delta-1. Sequence length is 1091 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Voltage-dependent L-type calcium channel subunit beta-1/alpha-1B/alpha-2/delta-1 as ChEMBL target CHEMBL3885653, mapped to UniProt P54290. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Voltage-dependent L-type calcium channel subunit beta-1/alpha-1B/alpha-2/delta-1 |
| Target Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
| UniProt | P54290 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Voltage-dependent calcium channel subunit alpha-2/delta-1 |
| UniProt Accession | P54290 |
| Component Type | Protein |
| Sequence Length | 1091 aa |
Voltage-dependent calcium channel subunit alpha-2/delta-1
Review this target as Voltage-dependent L-type calcium channel subunit beta-1/alpha-1B/alpha-2/delta-1, mapped to UniProt P54290. ChEMBL maps the protein component as Voltage-dependent calcium channel subunit alpha-2/delta-1. Sequence length is 1091 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL1088309 | 7.3 | IC50 | 50.0 | Preclinical |
| CHEMBL30008 | 7.1 | IC50 | 80.0 | Clinical |
| CHEMBL1087275 | 7.05 | IC50 | 90.0 | Preclinical |
| CHEMBL1087660 | 7.05 | IC50 | 90.0 | Preclinical |
| CHEMBL29188 | 7.05 | IC50 | 90.0 | Clinical |
| CHEMBL1086621 | 6.96 | IC50 | 110.0 | Preclinical |
| CHEMBL604710 | 6.96 | IC50 | 110.0 | Clinical |
| CHEMBL1088610 | 6.89 | IC50 | 130.0 | Preclinical |
| CHEMBL1087237 | 6.82 | IC50 | 150.0 | Preclinical |
| CHEMBL599217 | 6.82 | IC50 | 150.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 1 | 22 | 6.2 |