Mitogen-activated protein kinase kinase kinase 20 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt Q9NYL2. Use UniProt Q9NYL2 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q9NYL2 as the stable identity anchor, then attach disease evidence before program review.
Mitogen-activated protein kinase kinase kinase 20
Review this target as Mitogen-activated protein kinase kinase kinase 20, mapped to UniProt Q9NYL2. Sequence length is 800 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Mitogen-activated protein kinase kinase kinase 20 as ChEMBL target CHEMBL3886, mapped to UniProt Q9NYL2. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Mitogen-activated protein kinase kinase kinase 20 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q9NYL2 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Mitogen-activated protein kinase kinase kinase 20 |
| UniProt Accession | Q9NYL2 |
| Component Type | Protein |
| Sequence Length | 800 aa |
Mitogen-activated protein kinase kinase kinase 20
Review this target as Mitogen-activated protein kinase kinase kinase 20, mapped to UniProt Q9NYL2. Sequence length is 800 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4524151 | 8.72 | IC50 | 1.9 | Preclinical |
| CHEMBL4542865 | 8.68 | IC50 | 2.1 | Preclinical |
| CHEMBL574738 | 8.64 | Kd | 2.3 | Preclinical |
| CHEMBL4526537 | 8.64 | IC50 | 2.3 | Preclinical |
| CHEMBL4098896 | 8.57 | Kd | 2.7 | Preclinical |
| CHEMBL4574656 | 8.52 | IC50 | 3.0 | Preclinical |
| CHEMBL4098896 | 8.48 | IC50 | 3.3 | Preclinical |
| CHEMBL4579609 | 8.48 | IC50 | 3.3 | Preclinical |
| CHEMBL4446003 | 8.42 | IC50 | 3.8 | Preclinical |
| CHEMBL1229517 | 8.4 | IC50 | 4.0 | Approved |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 168 | 81 | 6.4 |
| assay format | 33 | 7 | 6.9 |
| cell-based format | 22 | 40 | 7.8 |
| subcellular format | 18 | 34 | 6.1 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 170 | 5.7 |