Sphingosine 1-phosphate receptor 3 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt Q99500. Use UniProt Q99500 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q99500 as the stable identity anchor, then attach disease evidence before program review.
Sphingosine 1-phosphate receptor 3
Review this target as Sphingosine 1-phosphate receptor 3, mapped to UniProt Q99500. Sequence length is 378 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Sphingosine 1-phosphate receptor 3 as ChEMBL target CHEMBL3892, mapped to UniProt Q99500. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Sphingosine 1-phosphate receptor 3 is the right protein anchor across sources, using UniProt Q99500 as the stable mapping.
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| Preferred Name | Sphingosine 1-phosphate receptor 3 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q99500 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Sphingosine 1-phosphate receptor 3 |
| UniProt Accession | Q99500 |
| Component Type | Protein |
| Sequence Length | 378 aa |
Sphingosine 1-phosphate receptor 3
Review this target as Sphingosine 1-phosphate receptor 3, mapped to UniProt Q99500. Sequence length is 378 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL225155 | 10.4 | IC50 | 0.04 | Preclinical |
| CHEMBL114606 | 10.0 | EC50 | 0.1 | Preclinical |
| CHEMBL366208 | 9.87 | EC50 | 0.134 | Preclinical |
| CHEMBL1089004 | 9.82 | EC50 | 0.15 | Preclinical |
| CHEMBL199791 | 9.75 | EC50 | 0.1778 | Preclinical |
| CHEMBL225155 | 9.7 | EC50 | 0.2 | Preclinical |
| CHEMBL1091103 | 9.67 | EC50 | 0.215 | Preclinical |
| CHEMBL1093686 | 9.54 | EC50 | 0.286 | Preclinical |
| CHEMBL473156 | 9.44 | IC50 | 0.36 | Preclinical |
| CHEMBL432067 | 9.15 | IC50 | 0.71 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 92 | 593 | 6.2 |
| assay format | 24 | 93 | 6.6 |
| cell membrane format | 3 | 21 | 5.4 |
| single protein format | 3 | 2 | 7.4 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 49 | 212 | 6.6 |
| single protein format | 34 | 638 | 6.6 |
| assay format | 6 | 19 | 6.2 |
| cell membrane format | 5 | 27 | 5.3 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 5 | 7 | 5.9 |
| assay format | 2 | 24 | 5.3 |
| cell membrane format | 1 | 1 | 8.4 |