Glutathione S-transferase P · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Glutathione S-transferase P shows clinical signal disease relevance led by myelodysplastic syndrome. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P09211. Start with myelodysplastic syndrome, then reuse UniProt P09211 as the stable protein anchor across project notes and exports.
Start with myelodysplastic syndrome, then reuse UniProt P09211 as the stable protein anchor across project notes and exports.
Glutathione S-transferase P shows clinical signal disease relevance led by myelodysplastic syndrome. 1 linked drug remains visible in the same block.
Start review with myelodysplastic syndrome because it currently carries clinical signal support. Linked drugs include EZATIOSTAT HYDROCHLORIDE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyGlutathione S-transferase P
Review this target as Glutathione S-transferase P, mapped to UniProt P09211. Sequence length is 210 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Glutathione S-transferase P as ChEMBL target CHEMBL3902, mapped to UniProt P09211. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Glutathione S-transferase P is the right protein anchor across sources, using UniProt P09211 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why myelodysplastic syndrome is currently framed as clinical signal support. It currently carries 1 linked drug in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
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| Preferred Name | Glutathione S-transferase P |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P09211 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Glutathione S-transferase P |
| UniProt Accession | P09211 |
| Component Type | Protein |
| Sequence Length | 210 aa |
Glutathione S-transferase P
Review this target as Glutathione S-transferase P, mapped to UniProt P09211. Sequence length is 210 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Glutathione S-transferase P shows clinical signal disease relevance led by myelodysplastic syndrome.
Start review with myelodysplastic syndrome because it currently carries clinical signal support. Linked drugs include EZATIOSTAT HYDROCHLORIDE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL379437 | 7.51 | IC50 | 31.0 | Preclinical |
| CHEMBL209755 | 7.34 | IC50 | 46.1 | Preclinical |
| CHEMBL4216562 | 7.29 | IC50 | 51.2 | Preclinical |
| CHEMBL3360520 | 7.0 | IC50 | 100.0 | Preclinical |
| CHEMBL3360523 | 7.0 | IC50 | 100.0 | Preclinical |
| CHEMBL442360 | 6.92 | Ki | 120.0 | Preclinical |
| CHEMBL216505 | 6.85 | IC50 | 142.0 | Preclinical |
| CHEMBL4757438 | 6.8 | IC50 | 160.0 | Preclinical |
| CHEMBL4757438 | 6.77 | Ki | 170.0 | Preclinical |
| CHEMBL3360504 | 6.7 | IC50 | 200.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 48 | 31 | 5.6 |
| single protein format | 36 | 121 | 5.7 |
| assay format | 5 | 2 | 5.8 |
| tissue-based format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 13 | 0 | — |
| cell-based format | 5 | 0 | — |