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Target Snapshot

CHEMBL3911 Target Snapshot

Leukotriene B4 receptor 1 · SINGLE PROTEIN · Homo sapiens

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701Compounds
190Assays
1Approved Drugs
640.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Leukotriene B4 receptor 1 shows clinical signal disease relevance led by asthma. 5 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt Q15722. Start with asthma, then reuse UniProt Q15722 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with asthma, then reuse UniProt Q15722 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13 1 linked drug
Open source guide
Disease program
asthma

Leukotriene B4 receptor 1 shows clinical signal disease relevance led by asthma. 5 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.

Start review with asthma because it currently carries clinical signal support. Linked drugs include AMELUBANT. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Clinical signal Open Targets-ready proxy 1 linked drug
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Leukotriene B4 receptor 1 as ChEMBL target CHEMBL3911, mapped to UniProt Q15722. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Leukotriene B4 receptor 1
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL3911
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q15722
Leukotriene B4 receptor 1
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Leukotriene B4 receptor 1 is the right protein anchor across sources, using UniProt Q15722 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why asthma is currently framed as clinical signal support. It currently carries 1 linked drug in the same disease frame.

Jump to Disease Context
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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameLeukotriene B4 receptor 1
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtQ15722
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelLeukotriene B4 receptor 1
UniProt AccessionQ15722
Component TypeProtein
Sequence Length352 aa

Leukotriene B4 receptor 1

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Leukotriene B4 receptor 1, mapped to UniProt Q15722. Sequence length is 352 aa.

Mapped IDQ15722
Review nameLeukotriene B4 receptor 1
OrganismHomo sapiens
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Clinical signal Open Targets-ready proxy

Leukotriene B4 receptor 1 shows clinical signal disease relevance led by asthma. 5 more disease programs remain visible in the same review block.

Clinical signal Phase II
asthma
1 linked drug · 1 direct · 1 efficacy
Linked drugAMELUBANT
Clinical signal Phase II
chronic obstructive pulmonary disease
1 linked drug · 1 direct · 1 efficacy
Linked drugAMELUBANT
Clinical signal Phase II
non-small cell lung carcinoma
1 linked drug · 1 direct · 1 efficacy
Linked drugETALOCIB
Clinical signal Phase II
pancreatic carcinoma
1 linked drug · 1 direct · 1 efficacy
Linked drugETALOCIB
Clinical signal Phase II
rheumatoid arthritis
1 linked drug · 1 direct · 1 efficacy
Linked drugAMELUBANT
Clinical signal Phase I
cystic fibrosis
1 linked drug · 1 direct · 1 efficacy
Linked drugAMELUBANT
Source · ChEMBL drug mechanism + indication proxy
ChEMBL target record ↗
Review Cue

How to read disease relevance

Start review with asthma because it currently carries clinical signal support. Linked drugs include AMELUBANT. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseaseasthma
Strongest levelClinical signal
Block modeOpen Targets-ready proxy
Clinical Profile

Clinical Phase Distribution

1
Approved
4
Phase II
2
Phase I
Assay Mix

Activity Type Distribution

IC50384.0
KI193.0
EC5063.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL292782 10.4 Ki 0.04 Preclinical
CHEMBL1099326 10.15 IC50 0.07 Preclinical
CHEMBL62265 10.14 Ki 0.073 Preclinical
CHEMBL422388 10.0 IC50 0.1 Preclinical
CHEMBL340460 9.96 Ki 0.11 Preclinical
CHEMBL65061 9.92 Ki 0.12 Preclinical
CHEMBL262231 9.85 Ki 0.14 Preclinical
CHEMBL328712 9.85 Ki 0.14 Preclinical
CHEMBL167350 9.82 IC50 0.15 Preclinical
CHEMBL1099335 9.74 IC50 0.18 Preclinical
Distribution

pChEMBL Value Distribution

30
5.0
43
5.5
70
6.0
79
6.5
96
7.0
101
7.5
101
8.0
36
8.5
25
9.0
11
9.5
pChEMBL
Approved Drugs

Approved Drugs

ZILEUTON
CHEMBL93
Approved 1996
Properties Compare Identifier
Assay Landscape

Assay Landscape

190
Total Assays
465
Tested Compounds
3
Assay Types
Binding — 136 assays, 465 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 88 158 7.4
cell-based format 16 66 7.0
tissue-based format 12 46 7.0
cell membrane format 11 95 7.4
assay format 9 100 7.1
Functional — 53 assays, 66 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 31 1 8.1
assay format 14 13 6.6
cell-based format 6 50 7.5
cell membrane format 1 1 8.0
tissue-based format 1 1 9.4
ADME — 1 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 1 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine