Thyroid hormone receptor beta · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-14Protein identity stays anchored to UniProt P18113. Use UniProt P18113 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P18113 as the stable identity anchor, then attach disease evidence before program review.
Thyroid hormone receptor beta
Review this target as Thyroid hormone receptor beta, mapped to UniProt P18113. Sequence length is 461 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Thyroid hormone receptor beta as ChEMBL target CHEMBL3917, mapped to UniProt P18113. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Thyroid hormone receptor beta is the right protein anchor across sources, using UniProt P18113 as the stable mapping.
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| Preferred Name | Thyroid hormone receptor beta |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | P18113 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Thyroid hormone receptor beta |
| UniProt Accession | P18113 |
| Component Type | Protein |
| Sequence Length | 461 aa |
Thyroid hormone receptor beta
Review this target as Thyroid hormone receptor beta, mapped to UniProt P18113. Sequence length is 461 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL163221 | 10.0 | IC50 | 0.1 | Preclinical |
| CHEMBL350265 | 10.0 | IC50 | 0.1 | Preclinical |
| CHEMBL289343 | 9.96 | IC50 | 0.11 | Preclinical |
| CHEMBL159682 | 9.85 | IC50 | 0.14 | Clinical |
| CHEMBL41632 | 9.82 | IC50 | 0.15 | Clinical |
| CHEMBL46882 | 9.72 | IC50 | 0.19 | Preclinical |
| CHEMBL350049 | 9.64 | IC50 | 0.23 | Preclinical |
| CHEMBL164421 | 9.59 | IC50 | 0.26 | Preclinical |
| CHEMBL163324 | 9.57 | IC50 | 0.27 | Preclinical |
| CHEMBL159976 | 9.51 | IC50 | 0.31 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 12 | 43 | 8.6 |
| organism-based format | 7 | 0 | — |
| cell-free format | 1 | 9 | 6.1 |
| tissue-based format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 5 | 0 | — |
| tissue-based format | 4 | 0 | — |
| organism-based format | 1 | 0 | — |