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Target Snapshot

CHEMBL3919 Target Snapshot

Potassium-transporting ATPase alpha chain 1 · SINGLE PROTEIN · Sus scrofa

64Compounds
10Assays
0Approved Drugs
44.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt P19156. Use UniProt P19156 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P19156 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Potassium-transporting ATPase alpha chain 1 as ChEMBL target CHEMBL3919, mapped to UniProt P19156. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Potassium-transporting ATPase alpha chain 1
SINGLE PROTEIN · Sus scrofa
As of 2026-09-13
ChEMBL target ID
CHEMBL3919
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P19156
Potassium-transporting ATPase alpha chain 1
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Potassium-transporting ATPase alpha chain 1 is the right protein anchor across sources, using UniProt P19156 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelPotassium-transporting ATPase alpha chain 1
UniProt AccessionP19156
Component TypeProtein
Sequence Length1034 aa

Potassium-transporting ATPase alpha chain 1

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Potassium-transporting ATPase alpha chain 1, mapped to UniProt P19156. Sequence length is 1034 aa.

Mapped IDP19156
Review namePotassium-transporting ATPase alpha chain 1
OrganismSus scrofa
Assay Mix

Activity Type Distribution

IC5041.0
KI3.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL47529 7.0 IC50 101.0 Preclinical
CHEMBL358421 6.77 IC50 170.0 Preclinical
CHEMBL151251 6.54 Ki 290.0 Preclinical
CHEMBL95108 6.54 Ki 290.0 Preclinical
CHEMBL346188 6.39 IC50 410.0 Preclinical
CHEMBL357193 6.38 IC50 420.0 Preclinical
CHEMBL137943 6.3 IC50 500.0 Preclinical
CHEMBL440726 6.28 IC50 530.0 Preclinical
CHEMBL298695 6.19 IC50 640.0 Preclinical
CHEMBL151251 6.18 IC50 660.0 Preclinical
Distribution

pChEMBL Value Distribution

6
5.0
12
5.5
11
6.0
3
6.5
1
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

10
Total Assays
44
Tested Compounds
1
Assay Types
Binding — 10 assays, 44 compounds
BAO Format Assays Compounds Avg pChEMBL
tissue-based format 6 41 5.6
single protein format 4 3 6.4

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine