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Target Snapshot

CHEMBL3920 Target Snapshot

Protein kinase C theta type · SINGLE PROTEIN · Homo sapiens

2,525Compounds
453Assays
9Approved Drugs
1,946.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt Q04759. Use UniProt Q04759 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q04759 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Protein kinase C theta type as ChEMBL target CHEMBL3920, mapped to UniProt Q04759. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Protein kinase C theta type
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL3920
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q04759
Protein kinase C theta type
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Protein kinase C theta type is the right protein anchor across sources, using UniProt Q04759 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelProtein kinase C theta type
UniProt AccessionQ04759
Component TypeProtein
Sequence Length706 aa

Protein kinase C theta type

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Protein kinase C theta type, mapped to UniProt Q04759. Sequence length is 706 aa.

Mapped IDQ04759
Review nameProtein kinase C theta type
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

9
Approved
8
Phase III
10
Phase II
11
Phase I
Assay Mix

Activity Type Distribution

IC501,100.0
KI485.0
EC5012.0
KD349.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL2326002 10.1 Ki 0.08 Preclinical
CHEMBL4082370 10.07 IC50 0.086 Preclinical
CHEMBL2325998 10.0 Ki 0.1 Preclinical
CHEMBL2326000 10.0 Ki 0.1 Preclinical
CHEMBL2326001 10.0 Ki 0.1 Preclinical
CHEMBL5632236 10.0 IC50 0.1 Preclinical
CHEMBL5631319 10.0 IC50 0.1 Preclinical
CHEMBL4578497 10.0 IC50 0.1 Preclinical
CHEMBL2151411 10.0 IC50 0.1 Preclinical
CHEMBL2148106 9.96 Ki 0.11 Preclinical
Distribution

pChEMBL Value Distribution

54
5.0
82
5.5
114
6.0
135
6.5
182
7.0
170
7.5
202
8.0
140
8.5
79
9.0
29
9.5
pChEMBL
Approved Drugs

Approved Drugs

PEXIDARTINIB
CHEMBL3813873
Approved 2019
MIDOSTAURIN
CHEMBL608533
Approved 2017
BOSUTINIB
CHEMBL288441
Approved 2012
DASATINIB
CHEMBL5416410
Approved 2006
Assay Landscape

Assay Landscape

453
Total Assays
1,020
Tested Compounds
2
Assay Types
Binding — 452 assays, 1,020 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 358 820 7.6
assay format 60 56 7.4
cell-based format 21 132 7.1
subcellular format 9 11 6.9
tissue-based format 4 1 6.5
Functional — 1 assays, 116 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 1 116 6.1

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine