Methionine aminopeptidase 2 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Methionine aminopeptidase 2 shows late clinical disease relevance led by obesity. 1 more disease program remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P50579. Start with obesity, then reuse UniProt P50579 as the stable protein anchor across project notes and exports.
Start with obesity, then reuse UniProt P50579 as the stable protein anchor across project notes and exports.
Methionine aminopeptidase 2 shows late clinical disease relevance led by obesity. 1 more disease program remain visible in the same review block. 1 linked drug remains visible in the same block.
Start review with obesity because it currently carries late clinical support. Linked drugs include BELORANIB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyMethionine aminopeptidase 2
Review this target as Methionine aminopeptidase 2, mapped to UniProt P50579. Sequence length is 478 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Methionine aminopeptidase 2 as ChEMBL target CHEMBL3922, mapped to UniProt P50579. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Methionine aminopeptidase 2 is the right protein anchor across sources, using UniProt P50579 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why obesity is currently framed as late clinical support. It currently carries 1 linked drug in the same disease frame.
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Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Methionine aminopeptidase 2 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P50579 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Methionine aminopeptidase 2 |
| UniProt Accession | P50579 |
| Component Type | Protein |
| Sequence Length | 478 aa |
Methionine aminopeptidase 2
Review this target as Methionine aminopeptidase 2, mapped to UniProt P50579. Sequence length is 478 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Methionine aminopeptidase 2 shows late clinical disease relevance led by obesity. 1 more disease program remain visible in the same review block.
Start review with obesity because it currently carries late clinical support. Linked drugs include BELORANIB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL243306 | 10.4 | Ki | 0.04 | Preclinical |
| CHEMBL241829 | 10.4 | Ki | 0.04 | Preclinical |
| CHEMBL397477 | 10.3 | Ki | 0.05 | Preclinical |
| CHEMBL243111 | 10.15 | Ki | 0.07 | Preclinical |
| CHEMBL3527358 | 10.02 | EC50 | 0.095 | Preclinical |
| CHEMBL242435 | 9.89 | Ki | 0.13 | Preclinical |
| CHEMBL245022 | 9.82 | Ki | 0.15 | Preclinical |
| CHEMBL245226 | 9.8 | Ki | 0.16 | Preclinical |
| CHEMBL4475680 | 9.8 | Ki | 0.16 | Preclinical |
| CHEMBL389087 | 9.64 | Ki | 0.23 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 72 | 877 | 6.9 |
| cell-based format | 28 | 164 | 6.5 |
| assay format | 4 | 97 | 7.3 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 5 | 2 | 7.1 |