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Target Snapshot

CHEMBL3946 Target Snapshot

Mannose-6-phosphate isomerase · SINGLE PROTEIN · Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

22Compounds
1Assays
0Approved Drugs
22.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P34948. Use UniProt P34948 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P34948 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Mannose-6-phosphate isomerase as ChEMBL target CHEMBL3946, mapped to UniProt P34948. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Mannose-6-phosphate isomerase
SINGLE PROTEIN · Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
As of 2026-09-14
ChEMBL target ID
CHEMBL3946
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P34948
Mannose-6-phosphate isomerase
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Mannose-6-phosphate isomerase is the right protein anchor across sources, using UniProt P34948 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelMannose-6-phosphate isomerase
UniProt AccessionP34948
Component TypeProtein
Sequence Length441 aa

Mannose-6-phosphate isomerase

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Mannose-6-phosphate isomerase, mapped to UniProt P34948. Sequence length is 441 aa.

Mapped IDP34948
Review nameMannose-6-phosphate isomerase
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Assay Mix

Activity Type Distribution

IC5022.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL75413 5.22 IC50 6000.0 Preclinical
CHEMBL74105 4.85 IC50 14000.0 Preclinical
CHEMBL75418 4.82 IC50 15000.0 Preclinical
CHEMBL75202 4.68 IC50 21000.0 Preclinical
CHEMBL75281 4.52 IC50 30000.0 Preclinical
CHEMBL72323 4.47 IC50 34000.0 Preclinical
CHEMBL76057 4.47 IC50 34000.0 Preclinical
CHEMBL75654 4.41 IC50 39000.0 Preclinical
CHEMBL75655 4.4 IC50 40000.0 Preclinical
CHEMBL306106 4.3 IC50 50000.0 Preclinical
Distribution

pChEMBL Value Distribution

1
5.0
0
5.5
0
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

1
Total Assays
13
Tested Compounds
1
Assay Types
Binding — 1 assays, 13 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 1 13 4.5

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine