Fibroblast growth factor receptor 4 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Fibroblast growth factor receptor 4 shows clinical signal disease relevance led by cancer. 1 more disease program remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P22455. Start with cancer, then reuse UniProt P22455 as the stable protein anchor across project notes and exports.
Start with cancer, then reuse UniProt P22455 as the stable protein anchor across project notes and exports.
Fibroblast growth factor receptor 4 shows clinical signal disease relevance led by cancer. 1 more disease program remain visible in the same review block. 1 linked drug remains visible in the same block.
Start review with cancer because it currently carries clinical signal support. Linked drugs include FGF401. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyFibroblast growth factor receptor 4
Review this target as Fibroblast growth factor receptor 4, mapped to UniProt P22455. Sequence length is 802 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Fibroblast growth factor receptor 4 as ChEMBL target CHEMBL3973, mapped to UniProt P22455. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Fibroblast growth factor receptor 4 is the right protein anchor across sources, using UniProt P22455 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why cancer is currently framed as clinical signal support. It currently carries 1 linked drug in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Fibroblast growth factor receptor 4 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P22455 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Fibroblast growth factor receptor 4 |
| UniProt Accession | P22455 |
| Component Type | Protein |
| Sequence Length | 802 aa |
Fibroblast growth factor receptor 4
Review this target as Fibroblast growth factor receptor 4, mapped to UniProt P22455. Sequence length is 802 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Fibroblast growth factor receptor 4 shows clinical signal disease relevance led by cancer. 1 more disease program remain visible in the same review block.
Start review with cancer because it currently carries clinical signal support. Linked drugs include FGF401. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3948579 | 10.0 | IC50 | 0.1 | Preclinical |
| CHEMBL3912731 | 9.7 | IC50 | 0.2 | Preclinical |
| CHEMBL3912896 | 9.7 | IC50 | 0.2 | Preclinical |
| CHEMBL3968338 | 9.7 | IC50 | 0.2 | Preclinical |
| CHEMBL4786195 | 9.7 | IC50 | 0.2 | Preclinical |
| CHEMBL5194425 | 9.6 | IC50 | 0.25 | Preclinical |
| CHEMBL3946444 | 9.52 | IC50 | 0.3 | Preclinical |
| CHEMBL3938786 | 9.52 | IC50 | 0.3 | Preclinical |
| CHEMBL3924363 | 9.52 | IC50 | 0.3 | Preclinical |
| CHEMBL3915180 | 9.52 | IC50 | 0.3 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 423 | 1,546 | 7.4 |
| cell-based format | 149 | 269 | 7.8 |
| assay format | 85 | 337 | 7.3 |
| tissue-based format | 77 | 0 | — |
| organism-based format | 2 | 60 | 6.9 |