Proteinase-activated receptor 1 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Proteinase-activated receptor 1 shows approved-linked disease relevance led by myocardial infarction. 4 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P25116. Start with myocardial infarction, then reuse UniProt P25116 as the stable protein anchor across project notes and exports.
Start with myocardial infarction, then reuse UniProt P25116 as the stable protein anchor across project notes and exports.
Proteinase-activated receptor 1 shows approved-linked disease relevance led by myocardial infarction. 4 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.
Start review with myocardial infarction because it currently carries approved-linked support. Linked drugs include VORAPAXAR SULFATE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyProteinase-activated receptor 1
Review this target as Proteinase-activated receptor 1, mapped to UniProt P25116. Sequence length is 425 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Proteinase-activated receptor 1 as ChEMBL target CHEMBL3974, mapped to UniProt P25116. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Proteinase-activated receptor 1 is the right protein anchor across sources, using UniProt P25116 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why myocardial infarction is currently framed as approved-linked support. It currently carries 1 linked drug in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Proteinase-activated receptor 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P25116 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Proteinase-activated receptor 1 |
| UniProt Accession | P25116 |
| Component Type | Protein |
| Sequence Length | 425 aa |
Proteinase-activated receptor 1
Review this target as Proteinase-activated receptor 1, mapped to UniProt P25116. Sequence length is 425 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Proteinase-activated receptor 1 shows approved-linked disease relevance led by myocardial infarction. 4 more disease programs remain visible in the same review block.
Start review with myocardial infarction because it currently carries approved-linked support. Linked drugs include VORAPAXAR SULFATE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL267059 | 10.4 | Kd | 0.04 | Preclinical |
| CHEMBL7642 | 9.82 | Kd | 0.15 | Preclinical |
| CHEMBL275003 | 9.36 | Kd | 0.44 | Preclinical |
| CHEMBL275946 | 9.15 | Kd | 0.7 | Preclinical |
| CHEMBL428311 | 9.09 | Kd | 0.82 | Preclinical |
| CHEMBL3954641 | 9.05 | IC50 | 0.9 | Preclinical |
| CHEMBL4111522 | 9.05 | IC50 | 0.9 | Preclinical |
| CHEMBL3939323 | 9.0 | IC50 | 0.99 | Preclinical |
| CHEMBL3942006 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL493982 | 8.96 | IC50 | 1.1 | Approved |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 32 | 333 | 7.2 |
| single protein format | 20 | 150 | 7.0 |
| cell-free format | 16 | 39 | 6.1 |
| cell membrane format | 12 | 170 | 7.0 |
| cell-based format | 8 | 94 | 5.7 |
| tissue-based format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 43 | 255 | 5.8 |
| cell-based format | 36 | 75 | 6.4 |
| cell-free format | 3 | 1 | 6.5 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-free format | 4 | 0 | — |