Dual specificity protein kinase TTK · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Dual specificity protein kinase TTK shows clinical signal disease relevance led by cancer. 2 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P33981. Start with cancer, then reuse UniProt P33981 as the stable protein anchor across project notes and exports.
Start with cancer, then reuse UniProt P33981 as the stable protein anchor across project notes and exports.
Dual specificity protein kinase TTK shows clinical signal disease relevance led by cancer. 2 linked drugs remain visible in the same block.
Start review with cancer because it currently carries clinical signal support. Linked drugs include BAY-1161909, BAY-1217389. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyDual specificity protein kinase TTK
Review this target as Dual specificity protein kinase TTK, mapped to UniProt P33981. Sequence length is 857 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Dual specificity protein kinase TTK as ChEMBL target CHEMBL3983, mapped to UniProt P33981. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Dual specificity protein kinase TTK is the right protein anchor across sources, using UniProt P33981 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why cancer is currently framed as clinical signal support. It currently carries 2 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Dual specificity protein kinase TTK |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P33981 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Dual specificity protein kinase TTK |
| UniProt Accession | P33981 |
| Component Type | Protein |
| Sequence Length | 857 aa |
Dual specificity protein kinase TTK
Review this target as Dual specificity protein kinase TTK, mapped to UniProt P33981. Sequence length is 857 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Dual specificity protein kinase TTK shows clinical signal disease relevance led by cancer.
Start review with cancer because it currently carries clinical signal support. Linked drugs include BAY-1161909, BAY-1217389. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4249882 | 10.33 | Ki | 0.047 | Preclinical |
| CHEMBL4877547 | 10.15 | Kd | 0.071 | Preclinical |
| CHEMBL3911532 | 10.08 | Ki | 0.084 | Preclinical |
| CHEMBL4245639 | 10.06 | Ki | 0.088 | Preclinical |
| CHEMBL3927553 | 10.03 | Ki | 0.094 | Preclinical |
| CHEMBL4469414 | 10.0 | Ki | 0.1 | Clinical |
| CHEMBL4632740 | 10.0 | IC50 | 0.1 | Preclinical |
| CHEMBL3924132 | 9.96 | Ki | 0.11 | Preclinical |
| CHEMBL4239476 | 9.96 | Ki | 0.11 | Preclinical |
| CHEMBL4240502 | 9.92 | Ki | 0.12 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 341 | 1,191 | 7.8 |
| cell-based format | 58 | 158 | 7.1 |
| assay format | 49 | 165 | 7.9 |
| subcellular format | 9 | 3 | 6.9 |
| organism-based format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 32 | 2 | 6.1 |