Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt Q99640. Use UniProt Q99640 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q99640 as the stable identity anchor, then attach disease evidence before program review.
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
Review this target as Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase, mapped to UniProt Q99640. Sequence length is 499 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase as ChEMBL target CHEMBL3984, mapped to UniProt Q99640. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q99640 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase |
| UniProt Accession | Q99640 |
| Component Type | Protein |
| Sequence Length | 499 aa |
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
Review this target as Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase, mapped to UniProt Q99640. Sequence length is 499 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4583196 | 9.3 | Ki | 0.5 | Preclinical |
| CHEMBL5416410 | 9.3 | Ki | 0.5 | Approved |
| CHEMBL49120 | 9.1 | Ki | 0.8 | Preclinical |
| CHEMBL5174684 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL5196713 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL5201803 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL5199076 | 8.7 | IC50 | 2.0 | Clinical |
| CHEMBL106772 | 8.64 | Ki | 2.3 | Preclinical |
| CHEMBL5190904 | 8.52 | IC50 | 3.0 | Preclinical |
| CHEMBL5172086 | 8.4 | IC50 | 4.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 86 | 57 | 6.1 |
| assay format | 18 | 44 | 6.6 |
| cell-based format | 16 | 54 | 7.1 |
| subcellular format | 9 | 4 | 5.9 |