Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex · SINGLE PROTEIN · Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
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As of 2026-09-14Protein identity stays anchored to UniProt P9WIS7. Use UniProt P9WIS7 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P9WIS7 as the stable identity anchor, then attach disease evidence before program review.
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
Review this target as Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mapped to UniProt P9WIS7. Sequence length is 553 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex as ChEMBL target CHEMBL3988584, mapped to UniProt P9WIS7. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex |
| Target Type | SINGLE PROTEIN |
| Organism | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
| UniProt | P9WIS7 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex |
| UniProt Accession | P9WIS7 |
| Component Type | Protein |
| Sequence Length | 553 aa |
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
Review this target as Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mapped to UniProt P9WIS7. Sequence length is 553 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3933712 | 6.85 | IC50 | 140.0 | Preclinical |
| CHEMBL2151190 | 6.36 | IC50 | 439.0 | Preclinical |
| CHEMBL3039201 | 6.35 | IC50 | 450.0 | Preclinical |
| CHEMBL3978318 | 6.17 | IC50 | 674.0 | Preclinical |
| CHEMBL433282 | 6.16 | IC50 | 691.0 | Preclinical |
| CHEMBL3905781 | 6.12 | IC50 | 760.0 | Preclinical |
| CHEMBL417727 | 6.1 | IC50 | 788.0 | Preclinical |
| CHEMBL3924071 | 6.02 | IC50 | 954.0 | Preclinical |
| CHEMBL3951719 | 5.95 | IC50 | 1130.0 | Preclinical |
| CHEMBL3893028 | 5.93 | IC50 | 1167.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 1 | 18 | 5.9 |