Dihydrofolate reductase · SINGLE PROTEIN · Streptococcus pyogenes
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As of 2026-09-14Protein identity stays anchored to UniProt J7IFZ2. Use UniProt J7IFZ2 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt J7IFZ2 as the stable identity anchor, then attach disease evidence before program review.
Dihydrofolate reductase
Review this target as Dihydrofolate reductase, mapped to UniProt J7IFZ2. Sequence length is 165 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Dihydrofolate reductase as ChEMBL target CHEMBL3988594, mapped to UniProt J7IFZ2. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Dihydrofolate reductase |
| Target Type | SINGLE PROTEIN |
| Organism | Streptococcus pyogenes |
| UniProt | J7IFZ2 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Dihydrofolate reductase |
| UniProt Accession | J7IFZ2 |
| Component Type | Protein |
| Sequence Length | 165 aa |
Dihydrofolate reductase
Review this target as Dihydrofolate reductase, mapped to UniProt J7IFZ2. Sequence length is 165 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL1270533 | 8.23 | IC50 | 5.9 | Preclinical |
| CHEMBL3526249 | 7.72 | IC50 | 19.0 | Preclinical |
| CHEMBL3234115 | 7.64 | IC50 | 23.0 | Preclinical |
| CHEMBL3644523 | 7.64 | IC50 | 23.0 | Preclinical |
| CHEMBL1270439 | 7.58 | IC50 | 26.0 | Preclinical |
| CHEMBL2335416 | 7.58 | IC50 | 26.0 | Preclinical |
| CHEMBL3644520 | 7.58 | IC50 | 26.0 | Preclinical |
| CHEMBL3219804 | 7.55 | IC50 | 28.0 | Preclinical |
| CHEMBL3644521 | 7.52 | IC50 | 30.0 | Preclinical |
| CHEMBL3644522 | 7.33 | IC50 | 47.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 1 | 15 | 7.4 |