Thyrotropin releasing hormone degrading enzyme · SINGLE PROTEIN · Sus scrofa
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As of 2026-09-14Protein identity stays anchored to UniProt F1SH20. Use UniProt F1SH20 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt F1SH20 as the stable identity anchor, then attach disease evidence before program review.
Thyrotropin releasing hormone degrading enzyme
Review this target as Thyrotropin releasing hormone degrading enzyme, mapped to UniProt F1SH20. Sequence length is 1044 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Thyrotropin releasing hormone degrading enzyme as ChEMBL target CHEMBL3988623, mapped to UniProt F1SH20. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Thyrotropin releasing hormone degrading enzyme |
| Target Type | SINGLE PROTEIN |
| Organism | Sus scrofa |
| UniProt | F1SH20 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Thyrotropin releasing hormone degrading enzyme |
| UniProt Accession | F1SH20 |
| Component Type | Protein |
| Sequence Length | 1044 aa |
Thyrotropin releasing hormone degrading enzyme
Review this target as Thyrotropin releasing hormone degrading enzyme, mapped to UniProt F1SH20. Sequence length is 1044 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3906398 | 6.39 | Ki | 410.0 | Preclinical |
| CHEMBL3926920 | 6.07 | Ki | 860.0 | Preclinical |
| CHEMBL3915933 | 5.76 | Ki | 1720.0 | Preclinical |
| CHEMBL3911902 | 5.49 | Ki | 3240.0 | Preclinical |
| CHEMBL3980061 | 5.18 | Ki | 6620.0 | Preclinical |
| CHEMBL3921638 | 5.03 | Ki | 9310.0 | Preclinical |
| CHEMBL3929592 | 5.0 | Ki | 9950.0 | Preclinical |
| CHEMBL3934622 | 4.94 | Ki | 11590.0 | Preclinical |
| CHEMBL3982251 | 4.93 | Ki | 11870.0 | Preclinical |
| CHEMBL3954284 | 4.76 | Ki | 17500.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 15 | 16 | 5.1 |