Voltage-dependent L-type calcium channel alpha1C/alpha2delta/beta1b · PROTEIN COMPLEX · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P54289. Use UniProt P54289 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P54289 as the stable identity anchor, then attach disease evidence before program review.
Voltage-dependent calcium channel subunit alpha-2/delta-1
Review this target as Voltage-dependent L-type calcium channel alpha1C/alpha2delta/beta1b, mapped to UniProt P54289. ChEMBL maps the protein component as Voltage-dependent calcium channel subunit alpha-2/delta-1. Sequence length is 1103 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Voltage-dependent L-type calcium channel alpha1C/alpha2delta/beta1b as ChEMBL target CHEMBL3988638, mapped to UniProt P54289. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Voltage-dependent L-type calcium channel alpha1C/alpha2delta/beta1b |
| Target Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
| UniProt | P54289 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Voltage-dependent calcium channel subunit alpha-2/delta-1 |
| UniProt Accession | P54289 |
| Component Type | Protein |
| Sequence Length | 1103 aa |
Voltage-dependent calcium channel subunit alpha-2/delta-1
Review this target as Voltage-dependent L-type calcium channel alpha1C/alpha2delta/beta1b, mapped to UniProt P54289. ChEMBL maps the protein component as Voltage-dependent calcium channel subunit alpha-2/delta-1. Sequence length is 1103 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL603465 | 6.21 | IC50 | 610.0 | Preclinical |
| CHEMBL596942 | 5.99 | IC50 | 1030.0 | Preclinical |
| CHEMBL597969 | 5.96 | IC50 | 1100.0 | Preclinical |
| CHEMBL605965 | 5.96 | IC50 | 1100.0 | Preclinical |
| CHEMBL589285 | 5.85 | IC50 | 1400.0 | Preclinical |
| CHEMBL598392 | 5.85 | IC50 | 1400.0 | Preclinical |
| CHEMBL599408 | 5.8 | IC50 | 1600.0 | Preclinical |
| CHEMBL606175 | 5.8 | IC50 | 1600.0 | Preclinical |
| CHEMBL597788 | 5.75 | IC50 | 1800.0 | Preclinical |
| CHEMBL599217 | 5.74 | IC50 | 1840.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 4 | 34 | 5.3 |