Hepcidin · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Hepcidin shows clinical signal disease relevance led by anemia (phenotype). 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P81172. Start with anemia (phenotype), then reuse UniProt P81172 as the stable protein anchor across project notes and exports.
Start with anemia (phenotype), then reuse UniProt P81172 as the stable protein anchor across project notes and exports.
Hepcidin shows clinical signal disease relevance led by anemia (phenotype). 1 linked drug remains visible in the same block.
Start review with anemia (phenotype) because it currently carries clinical signal support. Linked drugs include LY-2787106. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyHepcidin
Review this target as Hepcidin, mapped to UniProt P81172. Sequence length is 84 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Hepcidin as ChEMBL target CHEMBL3989381, mapped to UniProt P81172. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Hepcidin is the right protein anchor across sources, using UniProt P81172 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why anemia (phenotype) is currently framed as clinical signal support. It currently carries 1 linked drug in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Hepcidin |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P81172 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Hepcidin |
| UniProt Accession | P81172 |
| Component Type | Protein |
| Sequence Length | 84 aa |
Hepcidin
Review this target as Hepcidin, mapped to UniProt P81172. Sequence length is 84 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Hepcidin shows clinical signal disease relevance led by anemia (phenotype).
Start review with anemia (phenotype) because it currently carries clinical signal support. Linked drugs include LY-2787106. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5184000 | 8.14 | IC50 | 7.3 | Preclinical |
| CHEMBL5199417 | 7.55 | IC50 | 28.0 | Preclinical |
| CHEMBL5181536 | 7.47 | IC50 | 34.0 | Preclinical |
| CHEMBL5186341 | 7.24 | IC50 | 58.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 9 | 4 | 7.6 |