Isocitrate dehydrogenase [NADP], mitochondrial · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Isocitrate dehydrogenase [NADP], mitochondrial shows approved-linked disease relevance led by acute myeloid leukemia. 2 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P48735. Start with acute myeloid leukemia, then reuse UniProt P48735 as the stable protein anchor across project notes and exports.
Start with acute myeloid leukemia, then reuse UniProt P48735 as the stable protein anchor across project notes and exports.
Isocitrate dehydrogenase [NADP], mitochondrial shows approved-linked disease relevance led by acute myeloid leukemia. 2 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.
Start review with acute myeloid leukemia because it currently carries approved-linked support. Linked drugs include ENASIDENIB MESYLATE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyIsocitrate dehydrogenase [NADP], mitochondrial
Review this target as Isocitrate dehydrogenase [NADP], mitochondrial, mapped to UniProt P48735. Sequence length is 452 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Isocitrate dehydrogenase [NADP], mitochondrial as ChEMBL target CHEMBL3991501, mapped to UniProt P48735. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Isocitrate dehydrogenase [NADP], mitochondrial is the right protein anchor across sources, using UniProt P48735 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why acute myeloid leukemia is currently framed as approved-linked support. It currently carries 1 linked drug in the same disease frame.
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| Preferred Name | Isocitrate dehydrogenase [NADP], mitochondrial |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P48735 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Isocitrate dehydrogenase [NADP], mitochondrial |
| UniProt Accession | P48735 |
| Component Type | Protein |
| Sequence Length | 452 aa |
Isocitrate dehydrogenase [NADP], mitochondrial
Review this target as Isocitrate dehydrogenase [NADP], mitochondrial, mapped to UniProt P48735. Sequence length is 452 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Isocitrate dehydrogenase [NADP], mitochondrial shows approved-linked disease relevance led by acute myeloid leukemia. 2 more disease programs remain visible in the same review block.
Start review with acute myeloid leukemia because it currently carries approved-linked support. Linked drugs include ENASIDENIB MESYLATE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3752910 | 8.73 | Kd | 1.871 | Preclinical |
| CHEMBL4280772 | 8.52 | IC50 | 3.0 | Preclinical |
| CHEMBL4278420 | 8.4 | IC50 | 4.0 | Preclinical |
| CHEMBL5415614 | 8.32 | IC50 | 4.78 | Preclinical |
| CHEMBL4280132 | 8.22 | IC50 | 6.0 | Preclinical |
| CHEMBL4439421 | 8.22 | IC50 | 6.0 | Preclinical |
| CHEMBL4463644 | 8.22 | IC50 | 6.0 | Preclinical |
| CHEMBL4753099 | 8.21 | IC50 | 6.1 | Preclinical |
| CHEMBL4278845 | 8.15 | IC50 | 7.0 | Preclinical |
| CHEMBL4279047 | 8.15 | IC50 | 7.0 | Approved |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 52 | 383 | 6.4 |
| cell-based format | 14 | 68 | 7.3 |
| assay format | 13 | 22 | 6.2 |