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Target Snapshot

CHEMBL3999 Target Snapshot

Cell division protein FtsZ · SINGLE PROTEIN · Escherichia coli K-12

62Compounds
60Assays
0Approved Drugs
52.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P0A9A6. Use UniProt P0A9A6 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P0A9A6 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Cell division protein FtsZ as ChEMBL target CHEMBL3999, mapped to UniProt P0A9A6. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Cell division protein FtsZ
SINGLE PROTEIN · Escherichia coli K-12
As of 2026-09-14
ChEMBL target ID
CHEMBL3999
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P0A9A6
Cell division protein FtsZ
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Cell division protein FtsZ is the right protein anchor across sources, using UniProt P0A9A6 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelCell division protein FtsZ
UniProt AccessionP0A9A6
Component TypeProtein
Sequence Length383 aa

Cell division protein FtsZ

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Cell division protein FtsZ, mapped to UniProt P0A9A6. Sequence length is 383 aa.

Mapped IDP0A9A6
Review nameCell division protein FtsZ
OrganismEscherichia coli K-12
Clinical Profile

Clinical Phase Distribution

1
Phase II
2
Phase I
Assay Mix

Activity Type Distribution

IC5046.0
KD6.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL12089 7.64 Kd 23.0 Preclinical
CHEMBL417799 5.52 IC50 3000.0 Clinical
CHEMBL2180486 5.42 Kd 3800.0 Preclinical
CHEMBL293492 5.24 IC50 5810.0 Preclinical
CHEMBL3416824 5.08 IC50 8300.0 Preclinical
CHEMBL3425702 5.05 IC50 9000.0 Preclinical
CHEMBL12089 5.0 IC50 10000.0 Preclinical
CHEMBL294264 4.96 Kd 11000.0 Preclinical
CHEMBL3416948 4.92 IC50 12000.0 Preclinical
CHEMBL1835968 4.9 IC50 12500.0 Preclinical
Distribution

pChEMBL Value Distribution

6
5.0
1
5.5
0
6.0
0
6.5
0
7.0
1
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

60
Total Assays
27
Tested Compounds
1
Assay Types
Binding — 60 assays, 27 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 52 27 4.8
assay format 8 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine