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Target Snapshot

CHEMBL4001 Target Snapshot

Histone deacetylase 1 · SINGLE PROTEIN · Mus musculus

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62Compounds
21Assays
2Approved Drugs
87.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt O09106. Use UniProt O09106 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt O09106 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Histone deacetylase 1 as ChEMBL target CHEMBL4001, mapped to UniProt O09106. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Histone deacetylase 1
SINGLE PROTEIN · Mus musculus
As of 2026-09-13
ChEMBL target ID
CHEMBL4001
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
O09106
Histone deacetylase 1
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Histone deacetylase 1 is the right protein anchor across sources, using UniProt O09106 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NameHistone deacetylase 1
Target TypeSINGLE PROTEIN
OrganismMus musculus
UniProtO09106
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelHistone deacetylase 1
UniProt AccessionO09106
Component TypeProtein
Sequence Length482 aa

Histone deacetylase 1

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Histone deacetylase 1, mapped to UniProt O09106. Sequence length is 482 aa.

Mapped IDO09106
Review nameHistone deacetylase 1
OrganismMus musculus
Clinical Profile

Clinical Phase Distribution

2
Approved
2
Phase I
Assay Mix

Activity Type Distribution

IC5082.0
KI5.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL1790587 9.4 IC50 0.4 Preclinical
CHEMBL99 8.97 Ki 1.072 Preclinical
CHEMBL99 8.74 IC50 1.8 Preclinical
CHEMBL3647947 8.0 IC50 10.0 Preclinical
CHEMBL3647948 8.0 IC50 10.0 Preclinical
CHEMBL3647935 7.7 IC50 20.0 Preclinical
CHEMBL1790586 7.58 IC50 26.0 Preclinical
CHEMBL3647938 7.52 IC50 30.0 Preclinical
CHEMBL3647943 7.52 IC50 30.0 Preclinical
CHEMBL1790596 7.48 IC50 33.0 Preclinical
Distribution

pChEMBL Value Distribution

14
5.0
4
5.5
4
6.0
12
6.5
28
7.0
5
7.5
2
8.0
5
8.5
1
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

VORINOSTAT
CHEMBL98
Approved 2006
Properties Compare Identifier
Assay Landscape

Assay Landscape

21
Total Assays
63
Tested Compounds
1
Assay Types
Binding — 21 assays, 63 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 12 13 6.7
single protein format 6 44 6.7
assay format 3 6 7.4

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine